Department of Chemistry, Massachusetts Institute of Technology , 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
Inorg Chem. 2013 Sep 16;52(18):10394-406. doi: 10.1021/ic4011168. Epub 2013 Aug 26.
Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO2) in organic solvents. Palladium porphyrins are sensitive in the 0-160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Porphyrins with meso pyridyl substituents bind to the surface of the QD to produce self-assembled nanosensors. Appreciable overlap between QD emission and porphyrin absorption features results in efficient Förster resonance energy transfer (FRET) for signal transduction in these sensors. The QD serves as a photon antenna, enhancing porphyrin emission under both one- and two-photon excitation, demonstrating that QD-palladium porphyrin conjugates may be used for oxygen sensing over physiological oxygen ranges.
已开发出与钯（II）卟啉结合的量子点 (QD) 的超分子组装体，以检测有机溶剂中的氧气 (pO2)。钯卟啉在 0-160 托范围内敏感，使其成为体内生物氧定量的理想荧光团。具有中吡啶基取代基的卟啉结合到 QD 的表面以产生自组装纳米传感器。QD 发射和卟啉吸收特征之间的大量重叠导致这些传感器中的信号转导的有效Förster 共振能量转移 (FRET)。QD 作为光子天线，在单光子和双光子激发下增强卟啉的发射，证明 QD-钯卟啉缀合物可用于在生理氧范围内进行氧传感。
