构象控制能量转移：一种基于生物相容性纳米晶体的传感器的机制。
Conformational control of energy transfer: a mechanism for biocompatible nanocrystal-based sensors.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139-4307, USA.
出版信息
Angew Chem Int Ed Engl. 2013 Jan 21;52(4):1165-9. doi: 10.1002/anie.201207181. Epub 2012 Dec 6.
Abstract
: A new paradigm for designing self-referencing fluorescent nanosensors is demonstrated by interfacing a pH-triggered molecular conformational switch with quantum dots. Analytedependent, large-amplitude conformational motion controls the distance between the nanocrystal energy donor and an organic FRET acceptor. The result is a fluorescence signal capable of reporting pH values from individual endosomes in living cells.
摘要
: 通过将 pH 触发的分子构象开关与量子点相连接，展示了一种用于设计自参照荧光纳米传感器的新范例。分析依赖性的大振幅构象运动控制着纳米晶体供体与有机 FRET 受体之间的距离。其结果是产生了一种荧光信号，能够从活细胞的单个内涵体报告 pH 值。
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