芳香族硫代葡萄糖苷的合成及抗炎活性。
Synthesis and anti-inflammatory activity of aromatic glucosinolates.
机构信息
Department of Chemistry, La Trobe University, Victoria 3086, Australia.
出版信息
Bioorg Med Chem. 2013 Oct 1;21(19):5945-54. doi: 10.1016/j.bmc.2013.07.049. Epub 2013 Aug 9.
PMID:23978357
Abstract
Aromatic GLs are important members of the glucosinolate family of compounds because of their potential biological activity and medicinal properties. This study has shown success in the high yielding synthesis of some important aromatic GLs as well as the results of testing for anti-inflammatory properties of the synthetic GLs. 3,4-Dimethoxyphenylglucosinolate was found to be the most active anti-inflammatory of the seven glucosinolates assayed.
摘要
芳香族 GL 是硫代葡萄糖苷类化合物的重要成员，因为它们具有潜在的生物活性和药用特性。本研究成功地实现了一些重要芳香族 GL 的高产合成，并测试了合成 GL 的抗炎特性。在所测定的七种 GL 中，3,4-二甲氧基苯基 GL 是最具活性的抗炎 GL。
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