Xiao Jianchun, Zhao Zixuan, Li Binglu, Zhang Taiping
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
School of Medicine, Tsinghua University, Beijing, China.
Front Surg. 2021 May 21;8:642451. doi: 10.3389/fsurg.2021.642451. eCollection 2021.
To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma. In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019. Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters <10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients. The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.
探讨腹膜后神经节细胞瘤的临床特征、诊断、鉴别诊断、治疗方法及预后。在这项回顾性研究中，我们收集并分析了2012年10月至2019年8月期间在北京协和医院确诊为腹膜后神经节细胞瘤并入院的32例患者的临床资料。在我们的32例腹膜后神经节细胞瘤病例中，男女比例为1:3，平均年龄为35岁。仅25%的病例表现为腹痛，而超过65%的病例无特异性症状。仅5例患者通过体格检查发现肿块。大多数肿瘤位于肾区附近。它们通常为单发，呈浸润性生长模式，直径<10 cm，边界清晰，质地柔软。对于放射影像学检查，大多数肿瘤在CT成像上表现为软组织密度，有轻至中度强化，在超声检查中表现为低回声，有中等血流信号。大多数患者的实验室检查无明显异常。在所有32例患者中，2例因手术困难在活检后选择观察，其余患者选择手术切除。26例患者的平均随访时间为15.8个月。观察病例中的肿瘤保持稳定。4例接受手术的患者发现有残留肿瘤，无进展和不适。所有患者均未复发。腹膜后神经节细胞瘤是一种良性肿瘤，无特异性临床表现或明显的实验室检查结果。典型地，在放射影像学检查中表现为低密度，边界清晰，呈浸润性生长模式。总体预后良好。手术是一种有效的治疗方法，但可能会出现严重并发症。对于一些难以实现完全切除的病例，可以考虑不完全切除或观察。
