Williams Simon F, Rizk Said, Martin David P
Biomed Tech (Berl). 2013 Oct;58(5):439-52. doi: 10.1515/bmt-2013-0009.
Poly-4-hydroxybutyrate (P4HB) is a thermoplastic, linear polyester, produced by recombinant fermentation, that can be converted into a wide range of resorbable medical devices. P4HB fibers are exceptionally strong, and can be designed to provide prolonged strength retention in vivo. In 2007, the FDA cleared a monofilament suture made from P4HB for general soft tissue approximation and/or ligation. Subsequently, surgical mesh devices for hernia repair, tendon and ligament repair, and plastic and reconstructive surgery have been introduced for clinical use. This review describes the unique properties of P4HB, its clinical applications, and potential uses that are under development.
聚-4-羟基丁酸酯（P4HB）是一种通过重组发酵生产的热塑性线性聚酯，可转化为多种可吸收的医疗器械。P4HB纤维异常坚韧，可设计成在体内保持较长时间的强度。2007年，美国食品药品监督管理局（FDA）批准了一种由P4HB制成的单丝缝线用于一般软组织缝合和/或结扎。随后，用于疝气修复、肌腱和韧带修复以及整形和重建手术的外科补片装置已投入临床使用。本综述描述了P4HB的独特性能、其临床应用以及正在开发的潜在用途。
