Kalia Vipin Chandra, Patel Sanjay K S, Lee Jung-Kul
Department of Chemical Engineering, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, Republic of Korea.
Polymers (Basel). 2023 Apr 19;15(8):1937. doi: 10.3390/polym15081937.
Polyhydroxyalkanoates (PHA) are biodegradable plastic. Numerous bacteria produce PHAs under environmental stress conditions, such as excess carbon-rich organic matter and limitations of other nutritional elements such as potassium, magnesium, oxygen, phosphorus, and nitrogen. In addition to having physicochemical properties similar to fossil-fuel-based plastics, PHAs have unique features that make them ideal for medical devices, such as easy sterilization without damaging the material itself and easy dissolution following use. PHAs can replace traditional plastic materials used in the biomedical sector. PHAs can be used in a variety of biomedical applications, including medical devices, implants, drug delivery devices, wound dressings, artificial ligaments and tendons, and bone grafts. Unlike plastics, PHAs are not manufactured from petroleum products or fossil fuels and are, therefore, environment-friendly. In this review, a recent overview of applications of PHAs with special emphasis on biomedical sectors, including drug delivery, wound healing, tissue engineering, and biocontrols, are discussed.
聚羟基脂肪酸酯（PHA）是可生物降解的塑料。许多细菌在环境压力条件下产生PHA，例如存在过量的富含碳的有机物以及钾、镁、氧、磷和氮等其他营养元素受限的情况。除了具有与化石燃料基塑料相似的物理化学性质外，PHA还具有使其成为医疗设备理想材料的独特特性，例如易于灭菌且不会损坏材料本身，使用后易于溶解。PHA可以替代生物医学领域中使用的传统塑料材料。PHA可用于多种生物医学应用，包括医疗设备、植入物、药物递送装置、伤口敷料、人工韧带和肌腱以及骨移植。与塑料不同，PHA不是由石油产品或化石燃料制造的，因此对环境友好。在本综述中，将讨论PHA应用的最新概述，特别强调生物医学领域，包括药物递送、伤口愈合、组织工程和生物控制。
