HOXA-11 在子宫内膜异位症患者着床窗口期介导的基质重塑失调。
HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis.
机构信息
School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, Pin- 721 302, West Bengal, India.
出版信息
J Assist Reprod Genet. 2013 Nov;30(11):1505-12. doi: 10.1007/s10815-013-0088-9. Epub 2013 Aug 25.
PURPOSE
To investigate the Homeobox genes HOXA-10 and HOXA-11 mediated endometrial molecular defects during implantation window in endometriosis-associated infertility cases.
METHODS
Endometrial biopsies were obtained during implantation window from 31 infertile women with endometriosis (age < 35 years) and 26 age and BMI-matched infertile women without endometriosis were included in the study for comparison purposes. Endometrial expression of HOXA-10 and HOXA-11 genes, MMP-2, -9, α(v)β(3) integrin, leukemia inhibitory factor and surface characteristics including average roughness and topology were assessed.
RESULTS
A significantly lower expression of HOXA-10 and HOXA-11 were observed in endometriotic women compared to non-endometriotic controls. Further, a significantly higher endometrial expression of MMP-2 and -9 were observed in women with endometriosis when compared with controls. Interestingly, endometrial surface were observed to be grossly affected in terms of average roughness and topology in women with endometriosis compared to controls.
CONCLUSIONS
The findings suggest that aberrant expression of HOXA-10 and -11 genes adversely affects endometrial remodelling and expression of receptivity markers.
目的
研究 HOXA-10 和 HOXA-11 同源盒基因在子宫内膜异位症相关不孕病例种植窗期间介导的子宫内膜分子缺陷。
方法
在种植窗期间从 31 名患有子宫内膜异位症的不孕妇女（年龄<35 岁）和 26 名年龄和 BMI 匹配的无子宫内膜异位症的不孕妇女中获取子宫内膜活检，以进行比较研究。评估 HOXA-10 和 HOXA-11 基因、MMP-2、-9、α(v)β(3)整合素、白血病抑制因子和表面特征（包括平均粗糙度和拓扑结构）的表达。
结果
与非子宫内膜异位症对照组相比，子宫内膜异位症妇女的 HOXA-10 和 HOXA-11 表达明显降低。此外，与对照组相比，子宫内膜异位症妇女的 MMP-2 和 -9 表达明显升高。有趣的是，与对照组相比，子宫内膜异位症妇女的子宫内膜表面在平均粗糙度和拓扑结构方面明显受到影响。
结论
这些发现表明，HOXA-10 和 -11 基因的异常表达会对子宫内膜重塑和接受性标志物的表达产生不利影响。
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