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[南方红豆杉水提取物对肿瘤细胞增殖的抑制作用研究]

[Study on inhibitory effects of Taxus chinensis var. mairei aqueous extract on the proliferation of tumor cells].

作者信息

Zhang Jing, Shu Qi-Jin, Gao Ji-Liang, Zhang Le

机构信息

Tumor Department, Hangzhou Xiaoshan District Hospital of Traditional Chinese Medicine, Hangzhou 311200, China.

出版信息

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jun;33(6):805-9.

PMID:23980363
Abstract

OBJECTIVE

To study the inhibitory effects of Taxus chinensis var. mairei Aqueous Extract (TAE) on SGC-7901 and MCF-7 cells, and to explore its mechanisms.

METHODS

The inhibitory effects of TAT and Paclitaxel on the proliferation of SGC-7901 and MCF-7 cells were tested by MTT method. Their effects on the morphology of SGC-7901 and MCF-7 cells were observed by microscope. Its effects on the cell apoptosis were detected by flow cytometry.

RESULTS

The TAE had inhibitory effects on the proliferation of tumor cells, and its mechanisms were correlated to inducing the apoptosis of tumor cells.

CONCLUSION

TAE had inhibitory effects on the proliferation of tumor cells.

摘要

目的

研究南方红豆杉水提取物(TAE)对SGC - 7901和MCF - 7细胞的抑制作用,并探讨其作用机制。

方法

采用MTT法检测TAE和紫杉醇对SGC - 7901和MCF - 7细胞增殖的抑制作用。通过显微镜观察它们对SGC - 7901和MCF - 7细胞形态的影响。采用流式细胞术检测其对细胞凋亡的影响。

结果

TAE对肿瘤细胞增殖具有抑制作用,其机制与诱导肿瘤细胞凋亡有关。

结论

TAE对肿瘤细胞增殖具有抑制作用。

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Zhongguo Zhong Xi Yi Jie He Za Zhi. 2013 Jun;33(6):805-9.
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