Multiple Sclerosis Centre Hakadal, Norway, Oslo, Norway; Department of Neurology, Akershus University Hospital, Oslo, Norway.
Acta Neurol Scand. 2014 Apr;129(4):234-42. doi: 10.1111/ane.12177. Epub 2013 Aug 23.
To investigate executive complaints and objective executive deficits and their relations to both depression and neurological function in multiple sclerosis (MS).
One hundred and twenty MS patients participating in multidisciplinary rehabilitation underwent assessment with the Expanded Disability Status Scale (EDSS), neuropsychological tests of executive function, self-report measures of executive function (BRIEF-A), and depression (BDI-II).
Multivariate regression analysis showed that moderate depression and above (BDI-II > 20) significantly predicted a high degree of subjective executive complaints. Multivariate regression analysis showed that EDSS scores above 4.3 significantly predicted executive cognitive deficit, measured by neuropsychological tests.
Among the study variables, depression was the strongest predictor of executive complaints. A high degree of neurological disability was the strongest predictor for executive deficit, measured by neuropsychological tests.
探讨多发性硬化症（MS）患者的执行功能障碍和客观执行功能障碍及其与抑郁和神经功能的关系。
120 名参与多学科康复的 MS 患者接受了扩展残疾状况量表（EDSS）、执行功能神经心理学测试、执行功能自我报告量表（BRIEF-A）和抑郁（BDI-II）评估。
多变量回归分析显示，中重度抑郁（BDI-II>20）显著预测了较高程度的主观执行功能障碍。多变量回归分析显示，EDSS 评分>4.3 显著预测了神经心理学测试测量的执行认知障碍。
在研究变量中，抑郁是执行功能障碍的最强预测因素。神经功能障碍程度较高是神经心理学测试测量的执行功能障碍的最强预测因素。
