Thorenoor Nithyananda, Slaby Ondrej
Central European Institute of Technology, Masaryk University, Kamenice 753/5, 62500, Brno, Czech Republic.
Tumour Biol. 2015 Jan;36(1):41-53. doi: 10.1007/s13277-014-2818-8. Epub 2014 Nov 25.
Non-coding RNAs (ncRNAs) are important regulatory molecules involved in various physiological and pathological cellular processes. Small nucleolar RNAs (snoRNAs), subclass of small ncRNAs, have been considered important but unglamorous elements in the production of protein synthesis machinery of cells. However, recent evidence has indicated that these non-coding RNAs might have a crucial role also in controlling cell behavior, and snoRNAs dysfunction could significantly contribute to carcinogenesis. Here, we summarize the most important aspects of snoRNAs biology, their functioning in cancer cell, and potential usage in diagnosis or as a new class of therapeutic targets in cancer.
非编码RNA（ncRNAs）是参与各种细胞生理和病理过程的重要调节分子。小核仁RNA（snoRNAs）是小ncRNAs的一个亚类，一直被认为是细胞蛋白质合成机制产生过程中重要但不引人注目的元素。然而，最近的证据表明，这些非编码RNA在控制细胞行为方面可能也起着关键作用，并且snoRNAs功能障碍可能对癌症发生有显著影响。在这里，我们总结了snoRNAs生物学的最重要方面、它们在癌细胞中的功能，以及在癌症诊断中的潜在用途或作为一类新的治疗靶点。
