Amegbor K, Metowogo K, Eklu-Gadegbeku K, Agbonon A, Aklikokou K A, Napo-Koura G, Gbeassor M
Laboratoire d'Anatomie et Cytologie Pathologiques, Faculté Mixte de Médecine et de Pharmacie, Université de Lomé, Togo.
Afr J Tradit Complement Altern Med. 2012 Jul 1;9(4):584-90. doi: 10.4314/ajtcam.v9i4.16. eCollection 2012.
Vitex doniana is traditionally used in Togo to treat various diseases including wounds. The aim of this work was to evaluate the efficiency of Vitex doniana on cutaneous wound healing. Wounds were induced in ICR mice divided into four groups as following: Group I received carbopol 974P NF empty gel, Groups II and III were treated topically with carbopol gel containing 2.5% and 5% of Vitex doniana extract. Group IV received Betadine® 10% as standard drug. The efficacy of treatment was evaluated by planimetry and histological analysis. We secondary used the gel containing Vitex doniana at 2.5% and the pure extract at 10 mg/ml on the model of ear edema induced by xylene. Skin toxicity test was performed with the gel containing Vitex doniana at 5% and the pure extract at 30 mg/ml. Vitex doniana at 5% and 2.5% provided better wound contraction (91.14% and 86.38%) at day 12 post-excision when compared to control (51.15%). The results of histological evaluation supported the outcome of excision wound model. Moreover Vitex doniana inhibited significantly edema induced by xylene when compared to control (p< 0.05). In skin toxicity test, no abnormal symptoms were developed over 14 day-time period. Vitex doniana inhibits the topical inflammation and accelerate cutaneous wound repair.
在多哥，传统上使用非洲牡荆来治疗包括伤口在内的各种疾病。这项工作的目的是评估非洲牡荆对皮肤伤口愈合的效果。将ICR小鼠诱导形成伤口，分为四组如下：第一组接受卡波姆974P NF空凝胶，第二组和第三组分别用含有2.5%和5%非洲牡荆提取物的卡波姆凝胶局部治疗。第四组接受10%的聚维酮碘作为标准药物。通过平面测量法和组织学分析评估治疗效果。我们还在二甲苯诱导的耳水肿模型中使用了含2.5%非洲牡荆的凝胶和10 mg/ml的纯提取物。用含5%非洲牡荆的凝胶和30 mg/ml的纯提取物进行皮肤毒性试验。与对照组（51.15%）相比，5%和2.5%的非洲牡荆在切除术后第12天能提供更好的伤口收缩率（分别为91.14%和86.38%）。组织学评估结果支持切除伤口模型的结果。此外，与对照组相比，非洲牡荆能显著抑制二甲苯诱导的水肿（p<0.05）。在皮肤毒性试验中，在14天的时间段内未出现异常症状。非洲牡荆可抑制局部炎症并加速皮肤伤口修复。
