2011年伊斯法罕女性乳腺癌与复方口服避孕药消费模式之间关联的调查。

Investigation on the association between breast cancer and consumption patterns of combined oral contraceptive pills in the women of Isfahan in 2011.

作者信息

Ehsanpour Soheila, Nejad Fahime Seyed Ahmadi, Rajabi Fariborz Mokarian, Taleghani Fariba

机构信息

Department of Midwifery, Nursing and Midwifery Care Research Center, Isfahan, Iran.

出版信息

Iran J Nurs Midwifery Res. 2013 May;18(3):186-90.

PMID:23983752

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3748535/

Abstract

BACKGROUND

Oral contraceptive pills are among the most popular contraceptive methods, but the fear of cancer and cardiovascular disease overshadows its continuous use among women. This study aimed to define the association between consumption patterns of combined oral contraceptives among women with breast cancer.

MATERIALS AND METHODS

This is an analytical case-control study conducted on 175 women with breast cancer, referring to Seyed al Shohada Medical Center and private clinics in Isfahan to be treated and followed up in 2011, as well as 350 healthy women who were identical with the subjects in the study group regarding age and residential location. The data were collected using a researcher-made questionnaire. Content validity and Cronbach's alpha were employed to confirm validity and scientific reliability of the questionnaire, respectively. The data were analyzed by descriptive and analytical statistical methods through SPSS.

RESULTS

The findings showed that there was a significant association between history of contraceptive pills' consumption and incidence of breast cancer (P < 0.001). It was shown that the risk of developing breast cancer is increased by 2.27-fold among those with pills' consumption compared to those with no history of that. It was also shown that pills' consumption for 36-72 months increased the risk of breast cancer by 2.18-fold, the age of the first use being less than 20 years increased the risk by 3.28-fold, and time since the last use of less than 25 years increased the risk by 2.63-fold. There was no significant association between duration of use, age of the first and last use, and time since the first and last use in the study and control groups.

CONCLUSION

The results showed that history of pills' consumption is associated with incidence of breast cancer regardless of the consumption pattern. Use of oral contraceptives pills at any age and for any duration can increase the risk of breast cancer.

摘要

背景

口服避孕药是最受欢迎的避孕方法之一，但对癌症和心血管疾病的担忧使女性持续使用该药物蒙上阴影。本研究旨在确定乳腺癌女性中复方口服避孕药的消费模式之间的关联。

材料与方法

这是一项分析性病例对照研究，对2011年转诊至伊斯法罕的赛义德·阿尔·肖哈达医疗中心和私人诊所接受治疗及随访的175名乳腺癌女性，以及350名在年龄和居住地点方面与研究组对象相同的健康女性进行。数据通过研究者自制的问卷收集。分别采用内容效度和克朗巴哈系数来确认问卷的效度和科学可靠性。通过SPSS使用描述性和分析性统计方法对数据进行分析。

结果

研究结果表明，口服避孕药史与乳腺癌发病率之间存在显著关联（P < 0.001）。结果显示，与无口服避孕药史的女性相比，服用过避孕药的女性患乳腺癌的风险增加了2.27倍。还显示，服用避孕药36 - 72个月使患乳腺癌的风险增加了2.18倍，首次使用年龄小于20岁使风险增加了3.28倍，末次使用时间少于25年使风险增加了2.63倍。研究组和对照组在使用持续时间、首次和末次使用年龄以及首次和末次使用时间之间没有显著关联。