Chen Sheng, Wu Haijian, Klebe Damon, Hong Yuan, Zhang Jianmin, Tang Jiping
Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China.
Clin Dev Immunol. 2013;2013:689827. doi: 10.1155/2013/689827. Epub 2013 Aug 4.
Stroke is a common, debilitating trauma that has an incompletely elucidated pathophysiology and lacks an effective therapy. FoxP3(+)CD25(+)CD4(+) regulatory T cells (Tregs) suppress a variety of normal physiological and pathological immune responses via several pathways, such as inhibitory cytokine secretion, direct cytolysis induction, and antigen-presenting cell functional modulation. FoxP3(+)CD25(+)CD4(+) Tregs are involved in a variety of central nervous system diseases and injuries, including axonal injury, neurodegenerative diseases, and stroke. Specifically, FoxP3(+)CD25(+)CD4(+) Tregs exert neuroprotective effects in acute experimental stroke models. These beneficial effects, however, are difficult to elucidate. In this review, we summarized evidence of FoxP3(+)CD25(+)CD4(+) Tregs as potentially important immunomodulators in stroke pathogenesis and highlight further investigations for possible immunotherapeutic strategies by modulating the quantity and/or functional effects of FoxP3(+)CD25(+)CD4(+) Tregs in stroke patients.
中风是一种常见的使人衰弱的创伤，其病理生理学尚未完全阐明，且缺乏有效的治疗方法。叉头框蛋白P3（FoxP3）阳性、CD25阳性、CD4阳性调节性T细胞（Tregs）通过多种途径抑制多种正常生理和病理免疫反应，如抑制性细胞因子分泌、直接诱导细胞溶解以及调节抗原呈递细胞功能。FoxP3阳性、CD25阳性、CD4阳性Tregs参与多种中枢神经系统疾病和损伤，包括轴突损伤、神经退行性疾病和中风。具体而言，FoxP3阳性、CD25阳性、CD4阳性Tregs在急性实验性中风模型中发挥神经保护作用。然而，这些有益作用难以阐明。在本综述中，我们总结了FoxP3阳性、CD25阳性、CD4阳性Tregs作为中风发病机制中潜在重要免疫调节因子的证据，并强调通过调节中风患者体内FoxP3阳性、CD25阳性、CD4阳性Tregs的数量和/或功能效应来进行可能的免疫治疗策略的进一步研究。
