Department of Psychiatry, Christophsbad, Göppingen, Germany.
Ther Adv Psychopharmacol. 2012 Oct;2(5):199-205. doi: 10.1177/2045125312451270.
A 33-year-old female patient developed a hallucinogen-persisting perception disorder (HPPD) after lysergic acid diethylamide (LSD) abuse for a year at the age of 18. Specifically, she reported after images, perception of movement in her peripheral visual fields, blurring of small patterns, halo effects, and macro- and micropsia. Previous treatment with antidepressants and risperidone failed to ameliorate these symptoms. Upon commencing drug therapy with lamotrigine, these complex visual disturbances receded almost completely. Based on its hypothesized neuroprotective and mood-stabilizing effects, the antiepileptic lamotrigine may offer a promising new approach in the treatment of HPPD.
一位 33 岁女性患者，18 岁时因滥用 LSD 长达一年而出现致幻剂持续性知觉障碍（HPPD）。具体表现为：出现后像、感知到周边视野中的运动、小图案模糊、晕影效应、视幻觉和视微症。既往抗抑郁药和利培酮治疗均无效。加用氨己烯酸后，这些复杂的视觉障碍几乎完全消退。基于其假定的神经保护和稳定情绪作用，抗癫痫药氨己烯酸可能为 HPPD 的治疗提供一种有前途的新方法。
