Abraham H D, Mamen A
Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts, USA.
J Clin Psychopharmacol. 1996 Jun;16(3):238-41. doi: 10.1097/00004714-199606000-00008.
Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known to act in part at postsynaptic serotonin-2 receptors, it is noteworthy that three HPPD patients treated with risperidone reported an exacerbation of LSD-like panic and visual symptoms. We conclude that HPPD may be a relative contraindication for the use of risperidone.
利培酮是一种新型抗精神病药物，是突触后5-羟色胺-2和多巴胺D2受体的拮抗剂。在某些个体中，致幻药物麦角酸二乙酰胺（LSD）与明显终身持续的视觉障碍有关，在《精神疾病诊断与统计手册》第四版中被定义为致幻剂持续性感知障碍（HPPD）。由于已知LSD的致幻机制部分作用于突触后5-羟色胺-2受体，值得注意的是，三名接受利培酮治疗的HPPD患者报告称，LSD样的恐慌和视觉症状加重。我们得出结论，HPPD可能是使用利培酮的相对禁忌证。
