标准治疗剂量氯喹用于非复杂性疟疾后引起的急性肌张力障碍反应
Chloroquine-induced Acute Dystonic Reactions after a Standard Therapeutic Dose for Uncomplicated Malaria.
作者信息
Busari Olusegun A, Fadare Joseph, Agboola Segun, Gabriel Olusegun, Elegbede Olayide, Oladosu Yusuf
机构信息
Departments of Internal Medicine, Ido-Ekiti, Nigeria.
出版信息
Sultan Qaboos Univ Med J. 2013 Aug;13(3):E476-8. doi: 10.12816/0003278. Epub 2013 Jun 25.
Abstract
Acute dystonic reactions (ADR) are extrapyramidal effects that usually occur after the initiation of a wide variety of drugs or triggering factors besides neuroleptics. We report the case of a 54-year-old man who was admitted with an approximately 10-hour history of muscle twitching around the eyes, face and neck after he took the first dose of oral chloroquine phosphate (1 g [600 mg base]) prescribed for uncomplicated malaria. He was given intravenous diazepam (10 mg statum) followed by 10 mg of oral diazepam 3 times a day. The symptoms improved within 30 minutes of treatment, and he was discharged 14 hours later after a complete recovery.
摘要
急性肌张力障碍反应（ADR）是锥体外系效应，通常在开始使用除抗精神病药之外的多种药物或触发因素后发生。我们报告一例54岁男性病例，该患者因服用首剂口服磷酸氯喹（1克[600毫克碱基]）治疗非复杂性疟疾后，出现约10小时的眼周、面部和颈部肌肉抽搐病史而入院。给予其静脉注射地西泮（立即给予10毫克），随后每日3次口服地西泮10毫克。治疗后30分钟内症状改善，完全康复后14小时出院。
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Sultan Qaboos Univ Med J. 2011 Aug;11(3):377-82. Epub 2011 Aug 15.
2
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Ghana Med J. 2009 Sep;43(3):135-8. doi: 10.4314/gmj.v43i3.55340.
3
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4
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5
Chloroquine resistance before and after its withdrawal in Kenya.肯尼亚氯喹撤用前后的氯喹耐药性
Malar J. 2009 May 18;8:106. doi: 10.1186/1475-2875-8-106.
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