Han Chun-mao, Wang Xin-gang
Department of Burns, the Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, China.
Zhonghua Shao Shang Za Zhi. 2013 Apr;29(2):122-5.
Various skin defects resulting from mechanical injury, burns, chronic ulcers, and resection of tumor etc. are very common in clinic. The traditional treatment measure, such as grafting of autologous split-thickness skin remains the gold standard. However, its limitations are obvious, such as shortage of donor sites, creation of new injury, and scar formation. To realize regenerative or scarless repair of tissue defects has always been the dream of human being. The advent of tissue engineered skin (TES) provides an ideal access to tissue regeneration. After decades of development, several kinds of TES products have been developed and used in clinic, with promising effects. However, a large number of basic scientific problems regarding TES, as well as difficulties in translation of basic research to bedside should be taken into serious consideration. This article presents a comprehensive overview of strategies of construction of TES, the role of TES in regenerative wound repair, and its opportunities and challenges.
临床上，因机械损伤、烧伤、慢性溃疡以及肿瘤切除等导致的各种皮肤缺损十分常见。传统治疗手段，如自体中厚皮片移植仍是金标准。然而，其局限性明显，如供区不足、造成新的损伤以及形成瘢痕等。实现组织缺损的再生或无瘢痕修复一直是人类的梦想。组织工程皮肤（TES）的出现为组织再生提供了理想途径。经过数十年发展，已研发出多种TES产品并应用于临床，效果良好。然而，关于TES仍存在大量基础科学问题，以及基础研究转化至临床应用方面的困难，均应予以认真考虑。本文全面综述了TES构建策略、TES在再生性伤口修复中的作用及其机遇与挑战。
