Bürger R A, Gerharz C D, Bunn H, Engelmann U H, Hohenfellner R
Department of Urology, University Hospital, Mainz, Federal Republic of Germany.
J Urol. 1990 Oct;144(4):1000-3. doi: 10.1016/s0022-5347(17)39646-5.
In 65 male rats a comparative study was undertaken to investigate a Neodymium-YAG and CO2 laser system for the microsurgical repair of longitudinal incisions of the rat urethra. Postoperative investigations included patency tests, necropsy and light microscopy. Use of the laser systems did not reduce operation time. The highest rate of postoperative strictures (90%), urethral fistulas (30%), urinomas (20%) and postoperative deaths (70%) was seen in the Neodymium-YAG laser group. CO2 laser repair was almost as efficacious as microsuture repair, except for a higher rate of urethral fistulas resulting from the initially weak laser weld. Based on these findings, the Neodymium-YAG laser seems unsuitable for urethral repair. Further studies in larger animals are warranted using a CO2 laser in combination with postoperative cystostomy for urinary diversion in order to avoid fistulas in the early postoperative period.
对65只雄性大鼠进行了一项比较研究，以调查钕钇铝石榴石激光和二氧化碳激光系统用于大鼠尿道纵向切口显微外科修复的效果。术后检查包括通畅性测试、尸检和光学显微镜检查。使用激光系统并未缩短手术时间。钕钇铝石榴石激光组术后狭窄率最高（90%）、尿道瘘发生率为30%、尿囊肿发生率为20%、术后死亡率为70%。除了最初激光焊接较弱导致尿道瘘发生率较高外，二氧化碳激光修复几乎与显微缝合修复一样有效。基于这些发现，钕钇铝石榴石激光似乎不适合用于尿道修复。有必要在更大的动物中进行进一步研究，使用二氧化碳激光并结合术后膀胱造口术进行尿液转流，以避免术后早期出现瘘管。
