From the Memory and Aging Center (H.W.H., J.B.M., E.L.K., B.L.M., J.H.K., A.L.B.), Department of Neurology, University of California, San Francisco; and Frontotemporal Disorders Unit (B.C.D.), Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.
Neurology. 2013 Oct 1;81(14):1235-43. doi: 10.1212/WNL.0b013e3182a6cbfe. Epub 2013 Aug 28.
The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions.
We recorded eye movements in 182 subjects (NE: 118; MCI: 36; AD: 28) during an AS task. We also performed neuropsychological measures of executive function for comparison. Brain MRI scans were collected on most subjects, and cortical thickness was determined in 9 regions known to exhibit atrophy in AD dementia ("AD signature"). We investigated the relationships between AS and neuropsychological performance, as well as possible correlations between AS performance and cortical thickness.
AS performance in MCI resembled that in NE; subjects with AD were impaired relative to both MCI and NE. In all subjects, AS performance correlated with neuropsychological measures of executive function, even after controlling for disease severity. In the subjects with MCI but not in NE, cortical thickness in frontoparietal AD signature regions correlated with AS performance.
The AS task is a useful measure of executive function across the AD spectrum. In MCI, AS performance may reflect disease burden within cortical brain regions involved in oculomotor control; however, AS impairments in NE may have etiologies other than incipient AD.
本研究旨在通过反扫视（AS）任务来检测正常老年人（NE）和轻度认知障碍（MCI）及阿尔茨海默病（AD）患者的执行功能，并评估 AS 表现与 AD 相关区域皮质变薄之间的关系。
我们在 182 名受试者（NE：118；MCI：36；AD：28）进行 AS 任务期间记录了他们的眼球运动。我们还进行了神经心理学执行功能测试以作比较。大多数受试者接受了脑 MRI 扫描，在 9 个已知在 AD 痴呆中出现萎缩的区域（“AD 特征”）中确定了皮质厚度。我们研究了 AS 与神经心理学表现之间的关系，以及 AS 表现与皮质厚度之间的可能相关性。
MCI 受试者的 AS 表现与 NE 相似；而 AD 受试者的表现相对 MCI 和 NE 受损。在所有受试者中，AS 表现与执行功能的神经心理学测量相关，即使在控制疾病严重程度后也是如此。在 MCI 受试者中，但在 NE 受试者中，额顶叶 AD 特征区域的皮质厚度与 AS 表现相关。
AS 任务是 AD 谱中执行功能的有用测量方法。在 MCI 中，AS 表现可能反映了与眼球运动控制相关的皮质脑区的疾病负担；然而，NE 中的 AS 损伤可能有比早期 AD 更复杂的病因。
