沃尔巴克氏体介导的登革病毒干扰不需要 toll 和 IMD 途径。
The toll and Imd pathways are not required for wolbachia-mediated dengue virus interference.
机构信息
School of Biological Sciences, Monash University, Clayton, Victoria, Australia.
出版信息
J Virol. 2013 Nov;87(21):11945-9. doi: 10.1128/JVI.01522-13. Epub 2013 Aug 28.
Abstract
Wolbachia blocks dengue virus replication in Drosophila melanogaster as well as in Aedes aegypti. Using the Drosophila model and mutations in the Toll and Imd pathways, we showed that neither pathway is required for expression of the dengue virus-blocking phenotype in the Drosophila host. This provides additional evidence that the mechanistic basis of Wolbachia-mediated dengue virus blocking in insects is more complex than simple priming of the host insect innate immune system.
摘要
沃尔巴克氏体可阻断黑腹果蝇和埃及伊蚊中的登革热病毒复制。利用果蝇模型和 Toll 和 Imd 通路中的突变，我们发现这两条通路对于在果蝇宿主中表达登革热病毒阻断表型都不是必需的。这进一步证明了沃尔巴克氏体介导的昆虫中登革热病毒阻断的机制基础比简单地启动宿主昆虫先天免疫系统更为复杂。
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