Centre for Virus Research, University of Glasgow, Glasgow, UK.
Polo d'Innovazione di Genomica, Genetica e Biologia, Terni, Italy.
Pathog Glob Health. 2023 May;117(3):245-258. doi: 10.1080/20477724.2022.2117939. Epub 2022 Oct 7.
Following transfer into the primary arbovirus vector , several strains of the intracellular bacterium have been shown to inhibit the transmission of dengue, Zika, and chikungunya viruses, important human pathogens that cause significant morbidity and mortality worldwide. In addition to pathogen inhibition, many strains manipulate host reproduction, resulting in an invasive capacity of the bacterium in insect populations. This has led to the deployment of as a dengue control tool, and trials have reported significant reductions in transmission in release areas. Here, we discuss the possible mechanisms of -virus inhibition and the implications for long-term success of dengue control. We also consider the evidence presented in several reports that may cause an enhancement of replication of certain viruses under particular conditions, and conclude that these should not cause any concerns with respect to the application of to arbovirus control.
转入主要虫媒病毒载体后，几种胞内细菌已被证明可以抑制登革热、寨卡和基孔肯雅热病毒的传播，这些病毒是重要的人类病原体，在全球范围内造成了巨大的发病率和死亡率。除了抑制病原体外，许多菌株还操纵宿主繁殖，导致细菌在昆虫种群中具有侵袭能力。这导致了作为登革热控制工具的部署，试验报告称，在释放区的传播显著减少。在这里，我们讨论了 -病毒抑制的可能机制及其对登革热控制长期成功的影响。我们还考虑了几项报告中提出的证据，表明在某些条件下，可能会增强某些病毒的复制，我们的结论是，这些不应引起人们对应用于虫媒病毒控制的任何担忧。
