Wang Si-Hui, Xu Xiao-Ling, Chen Wei
Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, People's Republic of China.
Shulan International Medical College, Zhejiang Shuren University, Hangzhou, 310015, People's Republic of China.
Int J Nanomedicine. 2025 Jun 3;20:7133-7152. doi: 10.2147/IJN.S516260. eCollection 2025.
Inflammation is a protective response of the body, but when excessive or prolonged, it can contribute to disease progression and tissue damage. Identifying more effective and less toxic drugs for treating both acute and chronic inflammatory diseases is a major challenge. Organelle-targeting strategies, which deliver drugs directly to specific organelles, offer a promising solution by improving treatment efficiency and minimizing toxic effects on healthy cells. However, despite the potential of organelles as therapeutic targets, precise targeting remains challenging. This review systematically summarizes organelle-targeting nanodelivery strategies for major organelles-mitochondria, the endoplasmic reticulum, lysosomes, and the Golgi apparatus-and the research progress in evaluating the potential of these strategies for treating inflammation-related diseases. This study focuses on the applications of these strategies for the treatment of sepsis, inflammatory bowel disease, atherosclerosis, and osteoarthritis. Additionally, this review outlines future directions and key challenges in this field, aiming to provide a scientific reference for the application of organelle-targeting nanotherapeutics for the treatment of inflammatory diseases.
炎症是机体的一种保护反应，但当炎症过度或持续存在时，会促进疾病进展并导致组织损伤。确定更有效且毒性更小的药物来治疗急性和慢性炎症性疾病是一项重大挑战。细胞器靶向策略可将药物直接递送至特定细胞器，通过提高治疗效率并将对健康细胞的毒性作用降至最低，提供了一种有前景的解决方案。然而，尽管细胞器具有作为治疗靶点的潜力，但精确靶向仍然具有挑战性。本综述系统总结了针对主要细胞器（线粒体、内质网、溶酶体和高尔基体）的细胞器靶向纳米递送策略，以及评估这些策略治疗炎症相关疾病潜力的研究进展。本研究重点关注这些策略在治疗脓毒症、炎症性肠病、动脉粥样硬化和骨关节炎方面的应用。此外，本综述概述了该领域未来的方向和关键挑战，旨在为细胞器靶向纳米疗法治疗炎症性疾病的应用提供科学参考。
