Department of Physical Medicine and Rehabilitation, Izmir Katip Celebi University, Atatürk Training and Research Hospital, Basın Sitesi 35360, Izmir, Turkey.
Bosn J Basic Med Sci. 2013 Aug;13(3):192-6. doi: 10.17305/bjbms.2013.2361.
Obesity has a protective effect against osteoporosis and this effect has been attributed to a high body fat content. It has been shown that the leptin concentration is higher in obese patients. Leptin, the protein product of obesity gene, is a hormone produced in adipose tissue. Some studies suggest that endogenous leptin might influence bone metabolism in postmenopausal women. In this study, we investigated plasma leptin concentrations in postmenopausal women with osteoporosis and also analyzed the relationship between plasma leptin levels and bone mineral density (BMD) in order to understand the potential role of leptin in maintaining bone mass. Forty-two postmenopausal women with osteoporosis and thirty seven age and BMI-matched healthy postmenopausal women were included in the study. The mean femoral neck BMD value in the patient group was significantly lower than that in the control group (0.691±0.1 g/cm2 and 0.863±0.1 g/cm2, respectively; p<0.001). The mean plasma leptin concentration in the patient group was not significantly different from that in the control group (p>0.05). Plasma leptin levels were correlated with BMI in both groups (p<0.001 in the patient group and p=0.001 in controls). There was also a strong positive correlation between plasma leptin levels and %fat in both groups (p<0.001 in the patient group and p<0.001 in controls). But there was no correlation between plasma leptin levels and femoral neck BMD values in both groups. Our results do not support the hypothesis that leptin itself plays an important role in maintaining bone mass in postmenopausal women.
肥胖对骨质疏松有保护作用，这种作用归因于体脂含量高。已经表明，肥胖患者的瘦素浓度较高。瘦素是肥胖基因的蛋白产物，是脂肪组织产生的一种激素。一些研究表明，内源性瘦素可能会影响绝经后妇女的骨代谢。在这项研究中，我们调查了骨质疏松症绝经后妇女的血浆瘦素浓度，并分析了血浆瘦素水平与骨矿物质密度（BMD）之间的关系，以了解瘦素在维持骨量方面的潜在作用。研究纳入了 42 名骨质疏松症绝经后妇女和 37 名年龄和 BMI 匹配的健康绝经后妇女。患者组的股骨颈 BMD 值明显低于对照组（0.691±0.1 g/cm2 和 0.863±0.1 g/cm2，分别；p<0.001）。患者组的平均血浆瘦素浓度与对照组无显著差异（p>0.05）。两组的血浆瘦素水平均与 BMI 相关（患者组 p<0.001，对照组 p=0.001）。两组的血浆瘦素水平与脂肪百分比之间也存在强正相关（患者组 p<0.001，对照组 p<0.001）。但两组的血浆瘦素水平与股骨颈 BMD 值均无相关性。我们的结果不支持瘦素本身在绝经后妇女维持骨量方面发挥重要作用的假设。
