Jappinen A L, Kokki H, Rasi A S, Naaranlahti T J
Department of Pharmacy, Kuopio University Hospital, Kuopio, Finland.
Int J Pharm Compd. 1998 Nov-Dec;2(6):466-8.
Sufentanil is a potent micro-opioid and centrally acting analgesic. In the management of acute postoperative pain, sufentanil is often administered epidurally using a standard syringe pump. For epidural administration, sufentanil is diluted to a concentration of 1 to 2 micrograms/mL with 0.9% sodium chloride injection. The stability of sufentanil in a syringe pump under simulated epidural infusion was studied using a stability-indicating high-performance liquid chromatography method. The concentration of sufentanil was determined in polypropylene syringes connected with a polyethlyene or polyvinyl chloride (PVC) tubing, filter and epidural catheter. Sufentanil concentrations remained constant in polypropylene syringes connected to epidural catheters and in the whole epidural infusion system using polyethylene tubing. Sufentanil concentrations decreased 7% to 15% in syringes connected to PVC tubing, polyethylene tubing and the whole epidural infusion system using PVC tubing. Adsorption of 17% of the sufentanil onto an epidural filter occurred during the first hour of the infusion; thereafter, sufentanil concentration remained stable at levels that were 5% to 15% below the theoretical concentration. In conclusion, adsorption of sufentanil should be considered when a new filter and tubing of different materials are used.
舒芬太尼是一种强效的微阿片类和中枢性镇痛药。在急性术后疼痛管理中，舒芬太尼常通过标准注射泵进行硬膜外给药。对于硬膜外给药，舒芬太尼用0.9%氯化钠注射液稀释至浓度为1至2微克/毫升。采用一种稳定性指示高效液相色谱法研究了舒芬太尼在模拟硬膜外输注条件下于注射泵中的稳定性。在连接聚乙烯或聚氯乙烯（PVC）管路、过滤器和硬膜外导管的聚丙烯注射器中测定舒芬太尼的浓度。在连接硬膜外导管的聚丙烯注射器以及使用聚乙烯管路的整个硬膜外输注系统中，舒芬太尼浓度保持恒定。在连接PVC管路、聚乙烯管路以及使用PVC管路的整个硬膜外输注系统的注射器中，舒芬太尼浓度下降了7%至15%。在输注的第一个小时内，17%的舒芬太尼吸附到硬膜外过滤器上；此后，舒芬太尼浓度保持稳定，比理论浓度低5%至15%。总之，当使用不同材料的新过滤器和管路时，应考虑舒芬太尼的吸附情况。
