de Franciscis Stefano, Mastroroberto Pasquale, Gallelli Luca, Buffone Gianluca, Montemurro Rossella, Serra Raffaele
Department of Medical and Surgical Science, University Magna Graecia of Catanzaro, Catazaro, Italy.
Ann Vasc Surg. 2013 Nov;27(8):1185.e5-7. doi: 10.1016/j.avsg.2013.01.011. Epub 2013 Aug 26.
Matrix metalloproteinase-9 (MMP-9) is involved in the remodeling process by degrading extracellular matrix, which is fundamental in maintaining structural integrity and favorable mechanical properties of the artery vascular wall. Neutrophil gelatinase-associated lipocalin (NGAL) seems to enhance MMP-9 activity. ELISA test was used to evaluate plasma MMP-9 and NGAL values. Moreover, Western blot analysis and RT-PCR were used to evaluate expression of MMP-9 and NGAL in aneurysmatic tissue with respect to healthy endothelial tissue of the same patient. In this rare case of abdominal aortic aneurysm associated with multiple peripheral aneurysms, both plasma and tissue levels of MMP-9 and NGAL seemed to correlate with disease progression. More studies and clinical trials are necessary to confirm our findings.
基质金属蛋白酶-9（MMP-9）通过降解细胞外基质参与重塑过程，这对于维持动脉血管壁的结构完整性和良好的力学性能至关重要。中性粒细胞明胶酶相关脂质运载蛋白（NGAL）似乎可增强MMP-9的活性。采用酶联免疫吸附测定（ELISA）试验评估血浆MMP-9和NGAL值。此外，运用蛋白质印迹分析和逆转录聚合酶链反应（RT-PCR）评估同一患者动脉瘤组织中MMP-9和NGAL相对于健康内皮组织的表达。在这种伴有多个外周动脉瘤的腹主动脉瘤罕见病例中，MMP-9和NGAL的血浆及组织水平似乎均与疾病进展相关。需要更多的研究和临床试验来证实我们的发现。
