Grodberg David, Weinger Paige M, Halpern Danielle, Parides Michael, Kolevzon Alexander, Buxbaum Joseph D
Department of Psychiatry, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1230, New York, NY, USA,
J Autism Dev Disord. 2014 Mar;44(3):609-14. doi: 10.1007/s10803-013-1917-5.
The phenotypic heterogeneity of adults suspected of autism spectrum disorder (ASD) requires a standardized diagnostic approach that is feasible in all clinical settings. The autism mental status exam (AMSE) is an eight-item observational assessment that structures the observation and documentation of social, communicative and behavioral signs and symptoms of ASD. Previous findings indicate high classification accuracy when compared to the autism diagnostic observation schedule in a non-stratified population of high-risk patients suspected of having ASD. This protocol investigates the sensitivity and specificity of AMSE scores using DSM-5 criteria for ASD in a sample of high-risk verbally fluent adults. Findings indicate an optimized sensitivity of 0.91 and a specificity of 0.93 for this group. Because of its high clinical utility, the AMSE holds promise as a diagnostic assessment tool that can support one's clinical diagnosis of ASD in high-risk adults.
疑似患有自闭症谱系障碍（ASD）的成年人的表型异质性需要一种在所有临床环境中都可行的标准化诊断方法。自闭症精神状态检查（AMSE）是一项包含八个项目的观察性评估，它构建了对ASD的社交、沟通和行为体征及症状的观察与记录。先前的研究结果表明，在疑似患有ASD 的非分层高危患者群体中，与自闭症诊断观察量表相比，AMSE具有较高的分类准确性。本方案在一组能流利表达的高危成年样本中，使用DSM-5的ASD标准研究AMSE评分的敏感性和特异性。研究结果表明，该组的最佳敏感性为0.91，特异性为0.93。由于其较高的临床实用性，AMSE有望成为一种诊断评估工具，可辅助临床医生对高危成年人进行ASD的诊断。
