Wang Xiao-Qin, Liu Li, Liu Yong, Zhang Kui
1 Department of Pediatric Cardiology, West-China Second University Hospital , Sichuan University, Cheng Du, People's Republic of China .
Genet Test Mol Biomarkers. 2013 Dec;17(12):864-72. doi: 10.1089/gtmb.2013.0246. Epub 2013 Aug 30.
The ability to respond properly to Toll-like receptor (TLR) ligands may be impaired by polymorphisms within the TLR family of genes, which results in an altered susceptibility to cancers. However, the results of epidemiological studies remained inconsistent. To assess the effect of four selected polymorphisms (rs5743708, -196 to -174 del polymorphism, rs3804099, and rs3804100) in TLR-2 on cancer, we conducted a meta-analysis, up to November 2012; 20 case-control studies were available. Summary odds ratios (OR) and corresponding 95% confidence intervals (CIs) for polymorphisms in TLR-2 and cancer risk were estimated. Our meta-analysis identified that elevated cancer risk was statistically associated with -196 to -174 del allele in -196 to -174 del polymorphism (OR=1.63, 95% CI=1.10-2.41 for allele comparison; OR=1.64, 95% CI=1.05-2.57 for dominant model; OR=2.26, 95% CI=1.24-4.12 for recessive model; OR=2.57, 95% CI=1.30-5.08 for DD vs. II and OR=1.53, 95% CI=1.01-2.32 for ID vs. II in codominant model); whereas rs3804099 in TLR-2 was associated with decreased cancer risk. Moreover, in terms of stratified analyses by cancer type for -196 to -174 del polymorphism, significantly elevated risk was observed to be associated with -196 to -174 del allele in "other cancers." These findings indicate that polymorphisms in TLR-2 may play a role, although modest, in cancer development.
Toll样受体（TLR）基因家族内的多态性可能会损害对TLR配体的正常反应能力，从而导致患癌易感性改变。然而，流行病学研究结果仍不一致。为了评估TLR-2基因中四个选定的多态性（rs5743708、-196至-174缺失多态性、rs3804099和rs3804100）对癌症的影响，我们进行了一项截至2012年11月的荟萃分析；共有20项病例对照研究。估计了TLR-2基因多态性与癌症风险的汇总比值比（OR）及相应的95%置信区间（CI）。我们的荟萃分析发现，-196至-174缺失多态性中的-196至-174缺失等位基因与癌症风险升高在统计学上相关（等位基因比较时OR=1.63，95%CI=1.10-2.41；显性模型时OR=1.64，95%CI=1.05-2.57；隐性模型时OR=2.26，95%CI=1.24-4.12；共显性模型中DD与II比较时OR=2.57，95%CI=1.30-5.08，ID与II比较时OR=1.53，95%CI=1.01-2.32）；而TLR-2基因中的rs3804099与癌症风险降低相关。此外，就-196至-174缺失多态性按癌症类型进行的分层分析而言，在“其他癌症”中观察到-196至-174缺失等位基因与显著升高的风险相关。这些发现表明，TLR-2基因多态性可能在癌症发生发展中发挥作用，尽管作用不大。
