Department of Urology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.
The First Clinical College of Anhui Medical University, Hefei, Anhui, China.
Biosci Rep. 2019 Dec 20;39(12). doi: 10.1042/BSR20191698.
Relationship between Toll-like receptor-2 (TLR2) and cancer risk has been illustrated in some studies, but their conclusions are inconsistent. Therefore, we designed this meta-analysis to explore a more accurate conclusion of whether TLR2 affects cancer risks. Articles were retrieved from various literature databases according to the criteria. We used STATA to calculate the odds ratio (OR) and 95% confidence interval (95% CI) to evaluate the relationship between certain polymorphism of TLR2 and cancer risk. Finally, 47 case-control studies met the criteria, comprising 15851 cases and 21182 controls. In the overall analysis, people are more likely to get cancer because of -196 to -174del in TLR2 in all five genetic models, B vs. A (OR = 1.468, 95% Cl = 1.129-1.91, P=0.005); BB vs. AA (OR = 1.716, 95% Cl = 1.178-2.5, P=0.005); BA vs. AA (OR = 1.408, 95% Cl = 1.092-1.816, P=0.008); BB+BA vs. AA (OR = 1.449, 95% Cl = 1.107-1.897, P=0.007); BB vs. BA+AA (OR = 1.517, 95% Cl = 1.092-2.107, P=0.013). Meanwhile, rs4696480 could significantly increase the risk of cancer in Caucasians, furthermore, rs3804099 significantly decreased cancer risk in overall analysis, but more subjects are necessary to confirm the results. All in all, this meta-analysis revealed that not only -196 to -174del increased the risk of among overall cancers, Caucasians are more likely to get cancer because of rs4696480, while rs3804099 polymorphism could reduce the risk of cancer in some genetic models. There is no direct evidence showing that rs5743708, rs3804100 and rs1898830 are related to cancer.
TLR2 与癌症风险的关系在一些研究中已经得到了说明，但它们的结论并不一致。因此，我们设计了这项荟萃分析，以探讨 TLR2 是否影响癌症风险的更准确结论。根据标准，从各种文献数据库中检索到文章。我们使用 STATA 计算比值比（OR）和 95%置信区间（95%CI）来评估 TLR2 特定多态性与癌症风险之间的关系。最后，符合标准的 47 项病例对照研究纳入了 15851 例病例和 21182 例对照。在总体分析中，由于 TLR2 的-196 到-174del 缺失，所有人在所有五种遗传模型中都更容易患上癌症，B 对 A（OR=1.468，95%Cl=1.129-1.91，P=0.005）；BB 对 AA（OR=1.716，95%Cl=1.178-2.5，P=0.005）；BA 对 AA（OR=1.408，95%Cl=1.092-1.816，P=0.008）；BB+BA 对 AA（OR=1.449，95%Cl=1.107-1.897，P=0.007）；BB 对 BA+AA（OR=1.517，95%Cl=1.092-2.107，P=0.013）。同时，rs4696480 可显著增加白种人患癌症的风险，此外，rs3804099 可显著降低总体分析中的癌症风险，但需要更多的研究对象来确认结果。总而言之，这项荟萃分析表明，不仅-196 到-174del 增加了所有癌症的风险，白种人更容易因 rs4696480 而患上癌症，而 rs3804099 多态性可能会降低某些遗传模型中的癌症风险。没有直接证据表明 rs5743708、rs3804100 和 rs1898830 与癌症有关。
