Barthel E
Bezirksfachkrankenhaus für Lungenkrankheiten Amsee, Waren, DDR.
Pneumologie. 1990 Jul;44(7):883-6.
In a longitudinal study involving 109 patients suffering from silicosis, the development of lung function impairment was investigated. As a rule, functional disorders were found to develop only after the age of 50. Obstructive ventilation disturbances are by far the most common and are followed by restrictive disorders. Residual volume and arterial PO2 on physical exercise showed the highest rates of functional impairment and deterioration. The changeover to the more severely impaired groups occurred most quickly in the case of PO2--within a period of 4.3 +/- 2.2 years.
在一项涉及109例矽肺病患者的纵向研究中，对肺功能损害的发展情况进行了调查。通常情况下，功能障碍仅在50岁以后才会出现。阻塞性通气障碍是迄今为止最常见的，其次是限制性障碍。运动时的残气量和动脉血氧分压显示出最高的功能损害和恶化率。在血氧分压方面，向更严重受损组的转变发生得最快——在4.3±2.2年的时间内。
