二十碳五烯酸乙酯，一种纯 EPA ω-3 脂肪酸：对高甘油三酯血症患者的血浆和红细胞脂肪酸的影响（MARINE 研究结果）。
Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on plasma and red blood cell fatty acids in patients with very high triglyceride levels (results from the MARINE study).
机构信息
Amarin Pharma Inc., Bedminster, NJ 07921, USA.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 2013 Sep;89(4):195-201. doi: 10.1016/j.plefa.2013.07.005. Epub 2013 Aug 1.
INTRODUCTION
Icosapent ethyl (IPE) is a high-purity prescription form of eicosapentaenoic acid (EPA) ethyl ester. We evaluated IPE's effects on plasma and red blood cell (RBC) fatty acids (FA) and the relationship to triglyceride (TG) lowering.
MATERIALS AND METHODS
This was a predefined, exploratory analysis (N=229) of FA plasma concentration and RBC membrane content from the double-blind, placebo-controlled MARINE study.
RESULTS
Mean placebo-adjusted plasma EPA levels increased from baseline by 792% and 402% and the arachidonic acid/EPA plasma ratio decreased from baseline by 99% and 88% with IPE 4 g/day and 2 g/day, respectively (all P<.0001). Overall, the fractional pool of omega-3 FAs increased; there was a decrease or no change for omega-6 FAs. The increase in EPA levels with increased IPE dose corresponded with the TG-lowering effect. Similar FA shifts were observed in RBCs.
CONCLUSIONS
IPE significantly increased plasma and RBC FAs, which correlated to TG lowering.
简介
二十碳五烯酸乙酯（IPE）是一种高纯度的二十碳五烯酸（EPA）乙酯处方药。我们评估了 IPE 对血浆和红细胞（RBC）脂肪酸（FA）的影响及其与甘油三酯（TG）降低的关系。
材料与方法
这是一项双盲、安慰剂对照的 MARINE 研究中对 FA 血浆浓度和 RBC 膜含量的预先设定的探索性分析（N=229）。
结果
与安慰剂相比，IPE 4 g/天和 2 g/天组的 EPA 血浆水平分别增加了 792%和 402%，花生四烯酸/EPA 血浆比值分别降低了 99%和 88%（均 P<.0001）。总体而言，ω-3 脂肪酸的分数池增加，而 ω-6 脂肪酸减少或不变。随着 IPE 剂量的增加，EPA 水平的升高与 TG 降低的效果相对应。在 RBC 中也观察到了类似的 FA 变化。
结论
IPE 显著增加了血浆和 RBC 中的 FA，与 TG 降低相关。
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