Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven, CT 06510, USA.
Prog Cardiovasc Dis. 2013 Jul-Aug;56(1):74-80. doi: 10.1016/j.pcad.2013.05.007.
Thoracic aortic aneurysms (TAAs) are a prevalent and deadly disease that, without diagnosis and treatment, eventuates in life-threatening aortic dissection or rupture. While TAAs normally grow in an indolent manner, once a certain size (a "hinge point") is reached, the risk of dissection, rupture, and death increases dramatically. By virtue of their common clinical "silence," many TAAs are not diagnosed until such complications occur. While size is a helpful criterion for intervention, there is a need for parameters and markers besides aortic aneurysm size for use in diagnosing and monitoring TAAs so as to prevent natural complications of this disease.
胸主动脉瘤（TAAs）是一种普遍且致命的疾病，如果不进行诊断和治疗，最终会导致危及生命的主动脉夹层或破裂。虽然 TAAs 通常生长缓慢，但一旦达到一定大小（“临界点”），夹层、破裂和死亡的风险就会急剧增加。由于其常见的临床“沉默”，许多 TAA 在发生此类并发症之前都未被诊断出来。虽然大小是介入治疗的一个有用标准，但除了主动脉瘤大小之外，还需要其他参数和标志物来用于诊断和监测 TAA，以预防这种疾病的自然并发症。
