Qiu Guanguan, Yan Pengcheng, Shao Weiwei, Zhou Jie, Lin Weiwei, Fang Lianglian, Zhao Xiaowei, Dong Jianyong
School of Pharmacy, Wenzhou Medical University.
Chem Pharm Bull (Tokyo). 2013;61(9):983-6. doi: 10.1248/cpb.c13-00405.
Two new sesquiterpenoids, namely elema-1,3,7(11),8-tetraen-8,12-lactam (1) and 7β,8α-dihydroxy-1α,4αH-guai-9,11-dien-5β,8β-endoxide (2), together with five known analogs were isolated from the EtOAc extract of the rhizomes of Curcuma wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D-NMR techniques. All compounds were tested for the inhibition of lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Compound 1 showed the significant inhibitory activity with IC50 values of 9.4 µM.
从温郁金根茎的乙酸乙酯提取物中分离出两种新的倍半萜类化合物，即榄香-1,3,7(11),8-四烯-8,12-内酰胺（1）和7β,8α-二羟基-1α,4αH-愈创木-9,11-二烯-5β,8β-环氧化物（2），以及五个已知类似物。通过包括二维核磁共振技术在内的光谱方法确定了它们的结构和相对构型。对所有化合物进行了抑制脂多糖（LPS）诱导的一氧化氮（NO）生成的测试。化合物1表现出显著的抑制活性，IC50值为9.4μM。
