Institute of Analytical and Bioanalytical Chemistry, University of Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany.
Chem Soc Rev. 2013 Nov 21;42(22):8683-99. doi: 10.1039/c3cs60173k.
Despite providing the opportunity for directly sensing molecular constituents with inherent fingerprint specificity in the 2.5-20 μm spectral regime, mid-infrared optical sensing technologies have not yet achieved the same penetration in waveguide-based chem/bio sensing compared to related sensing schemes operating at visible and near-infrared frequencies. In this review, current advances in mid-infrared chem/bio sensor technology will be highlighted and contrasted with the prevalent bottlenecks that have to date limited a more widespread adoption of mid-infrared sensing devices. However, with the increasing availability of advanced light sources such as quantum cascade lasers and the advent of on-chip semiconductor waveguide technologies, a prosperous future of this sensing concept for label-free detection in environmental analysis, process monitoring, and bioanalytics is perceived.
尽管在 2.5-20 μm 的光谱范围内提供了直接感应具有固有指纹特异性的分子成分的机会,但与在可见和近红外频率下运行的相关传感方案相比,中红外光学传感技术在基于波导的化学/生物传感方面尚未达到相同的渗透水平。在这篇综述中,将重点介绍中红外化学/生物传感器技术的当前进展,并与迄今为止限制更广泛采用中红外传感设备的流行瓶颈进行对比。然而,随着诸如量子级联激光器等先进光源的日益普及,以及片上半导体波导技术的出现,人们认为这种用于环境分析、过程监测和生物分析的无标记检测的传感概念将拥有美好的未来。