Hafezi Wali, Hoerr Verena
Institute of Medical Microbiology Clinical Virology, University Hospital Münster, Münster, Germany.
Methods Mol Biol. 2013;1064:253-65. doi: 10.1007/978-1-62703-601-6_18.
Herpes simplex encephalitis (HSE) is one of the most severe viral infections affecting the temporal lobes of the brain. Despite the improvements in diagnosis and antiviral drug treatment, one third of all patients fail to respond to therapy or subsequently suffer neurological relapse and develop long term neurological damage. Magnetic resonance imaging (MRI) is among the appropriate noninvasive tools for early diagnosis of viral central nervous system (CNS) infections. In this chapter we introduce a mouse model for HSE and describe a MRI protocol to characterize the pathogenesis of HSE over time.
单纯疱疹性脑炎（HSE）是影响脑颞叶的最严重病毒感染之一。尽管在诊断和抗病毒药物治疗方面有所改进，但所有患者中有三分之一对治疗无反应，或随后出现神经复发并发展为长期神经损伤。磁共振成像（MRI）是早期诊断病毒性中枢神经系统（CNS）感染的合适非侵入性工具之一。在本章中，我们介绍一种HSE小鼠模型，并描述一种MRI方案，以随时间推移表征HSE的发病机制。
