Laboratory of Advanced Materials Department of Chemistry, Fudan University, Shanghai, 200433, China.
Adv Mater. 2013 Dec 3;25(45):6569-74. doi: 10.1002/adma.201303124. Epub 2013 Sep 1.
A FRET-based carbon nanodot (CDot) drug delivery platform has been developed. These CDots offer excellent biocompatibility, stable fluorescence, and efficient FRET between CDots and the attached fluorescent drug molecules, such as doxorubicin, enabling enhanced drug delivery, convenient cell imaging, and real-time monitoring of drug release. Moreover, the FRET-based two-photon imaging and drug tracking in deep tissues are also demonstrated.
一种基于荧光共振能量转移（FRET）的碳纳米点（CDot）药物传递平台已经被开发出来。这些 CDots 具有极好的生物相容性、稳定的荧光性质，并且 CDots 与附着的荧光药物分子（如阿霉素）之间具有高效的 FRET，从而实现了增强的药物传递、方便的细胞成像以及药物释放的实时监测。此外，还证明了基于 FRET 的双光子成像和药物在深部组织中的追踪。
