Kucherenko Sergei
Department of Chemical Engineering and Chemical Technology, Imperial College London, London, UK.
Methods Mol Biol. 2013;1073:191-224. doi: 10.1007/978-1-62703-625-2_16.
One of the dominant approaches in synthetic biology is the development and implementation of minimal circuits that generate reproducible and controllable system behavior. However, most biological systems are highly complicated and the design of sustainable minimal circuits can be challenging. SobolHDMR is a general-purpose metamodeling software that can be used to reduce the complexity of mathematical models, such as those for metabolic networks and other biological pathways, yielding simpler descriptions that retain the features of the original model. These descriptions can be used as the basis for the design of minimal circuits or artificial networks.
合成生物学的主要方法之一是开发和实施能够产生可重复和可控系统行为的最小电路。然而，大多数生物系统高度复杂，设计可持续的最小电路可能具有挑战性。SobolHDMR是一种通用的元建模软件，可用于降低数学模型的复杂性，例如代谢网络和其他生物途径的模型，从而产生保留原始模型特征的更简单描述。这些描述可作为设计最小电路或人工网络的基础。
