Kang Jeeun, Kim Eun-Kyung, Kim Ga Ram, Yoon Changhan, Song Tai-Kyong, Chang Jin Ho
Department of Electronic Engineering, Sogang University, Seoul, 121-742, Korea.
J Biophotonics. 2015 Jan;8(1-2):71-80. doi: 10.1002/jbio.201300100. Epub 2013 Sep 2.
This paper investigates whether photoacoustic imaging (PAI) can provide the visualization of microcalcifications in breast tissue. For this, the geometrical correlation between the 3-D PA images of breast microcalcifications within ex vivo specimens and the corresponding mammograms was ascertained. Also, the optical absorbance of the calcification compositions (i.e., hydroxyapatite and calcium oxalate) was measured and compared with the PA responses of the microcalcifications. The experimental results demonstrated that the PA images discriminated between the microcalcifications and the surrounding tissue, and their locations in PA images reasonably meshed with those of the microcalcifications appeared in the mammograms. Also, the change in PA signal amplitude along the laser wavelength agreed with the absorbance of hydroxyapatite associated with the relatively high potential of malignant cancers, but not calcium oxalate with only benign cases.
本文研究了光声成像（PAI）是否能够实现乳腺组织中微钙化的可视化。为此，确定了离体标本内乳腺微钙化的三维PA图像与相应乳腺X线照片之间的几何相关性。此外，还测量了钙化成分（即羟基磷灰石和草酸钙）的光吸收率，并将其与微钙化的PA响应进行了比较。实验结果表明，PA图像能够区分微钙化与周围组织，并且它们在PA图像中的位置与乳腺X线照片中出现的微钙化位置合理匹配。此外，PA信号幅度沿激光波长的变化与与恶性癌症相对高可能性相关的羟基磷灰石的吸收率一致，但与仅为良性病例的草酸钙的吸收率不一致。
