Yadav Rakhee, Bhartiya Jai Prakash, Verma Sunil Kumar, Nandkeoliar Manoj Kumar
Senior Resident, Department of Clinical Biochemistry, Vardhman Mahavir Medical College & Safdarjung Hospital New Delhi, India .
J Clin Diagn Res. 2013 Jul;7(7):1291-4. doi: 10.7860/JCDR/2013/6016.3120. Epub 2013 Jul 1.
Diabetes mellitus is a chronic metabolic disorder which is associated with hyperglycaemia. It is caused by a derangement in the secretion or function of the endocrinal portion of the pancreas. There is a close anatomical and functional relationship between its exocrine and endocrine portions. To address this issue, the current study was designed to evaluate the blood glucose and the amylase levels of diabetic patients as representatives of the two portions of the pancreas respectively.
The aim of the present study was to determine the blood glucose, serum amylase and the serum lipid profile in known cases of type 2 Diabetes Mellitus and to compare and correlate these parameters with those of age and sex matched healthy controls.
One hundred ten patients of type 2 Diabetes mellitus, who were already diagnosed and were taking treatment, were included in this study. 30 age and sex matched healthy individuals were recruited as the control group in our study. Fasting venous blood samples were collected from the patients as well as the controls and they were analysed by using an automated analyser for blood glucose, serum amylase and the lipid profile (serum triglycerides, total cholesterol, high density lipoproteins and low density lipoproteins). The results were analyzed statistically by using the Student's "t" test and correlation coefficients.
Significantly low serum amylase levels were found in the diabetic patients as compared to those in the healthy controls (p value <0.001). Also, the levels of fasting serum total cholesterol, triglycerides and the low density lipoproteins were significantly higher in the patients as compared to those in the controls, with p values of <0.05, <0.001 and <0.001 respectively. The HDL (high density lipoprotein) level was found to be lower in the diabetic patients (p value <0.001).
From our study, it was concluded that in type 2 Diabetes mellitus, wherever the blood glucose level was higher, the serum amylase activity was found to be significantly lower. This reflected the derangement in the endocrine-exocrine axis of the pancreas, as a disease which affected any portion of an organ would affect the adjoining area of that organ functionally. This fact must be kept in mind while the patients are treated.
糖尿病是一种与高血糖相关的慢性代谢紊乱疾病。它由胰腺内分泌部分的分泌或功能紊乱引起。胰腺的外分泌和内分泌部分之间存在密切的解剖学和功能关系。为解决这一问题，本研究旨在分别评估糖尿病患者作为胰腺两部分代表的血糖和淀粉酶水平。
本研究的目的是测定2型糖尿病已知病例的血糖、血清淀粉酶和血清脂质谱，并将这些参数与年龄和性别匹配的健康对照者的参数进行比较和关联。
本研究纳入了110例已确诊并正在接受治疗的2型糖尿病患者。招募30名年龄和性别匹配的健康个体作为对照组。从患者和对照者采集空腹静脉血样本，并使用自动分析仪分析血糖、血清淀粉酶和脂质谱（血清甘油三酯、总胆固醇、高密度脂蛋白和低密度脂蛋白）。结果采用学生“t”检验和相关系数进行统计学分析。
与健康对照者相比，糖尿病患者的血清淀粉酶水平显著降低（p值<0.001）。此外，患者的空腹血清总胆固醇、甘油三酯和低密度脂蛋白水平显著高于对照者，p值分别为<0.05、<0.001和<0.001。糖尿病患者的高密度脂蛋白（HDL）水平较低（p值<0.001）。
从我们的研究得出结论，在2型糖尿病中，无论血糖水平多高，血清淀粉酶活性均显著降低。这反映了胰腺内分泌-外分泌轴的紊乱，因为影响一个器官任何部分的疾病都会在功能上影响该器官的相邻区域。在治疗患者时必须牢记这一事实。
