Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland.
Fertil Steril. 2013 Dec;100(6):1727-34. doi: 10.1016/j.fertnstert.2013.08.002. Epub 2013 Aug 31.
To assess the association of total isoflavone intake with ovulatory function, including sporadic anovulation in healthy premenopausal women.
Prospective cohort study.
University.
PATIENT(S): Participants included 259 healthy regularly menstruating women aged 18-44 years.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Serum concentrations of E2, free E2, P, LH, FSH, and SHBG and sporadic anovulation in healthy premenopausal women.
RESULT(S): Isoflavone intake was not associated with E2, free E2, P, LH, and FSH concentrations. Consumption in the highest quartile (Q4: 1.6-78.8 mg/d) was significantly associated with greater SHBG concentrations (β = 0.09; 95% confidence interval [CI] 0.02-0.16), compared with the first quartile (Q1: 0.0-0.3 mg/d).
CONCLUSION(S): Isoflavone intake was not associated with sporadic anovulation (Q4 vs. Q1: odds ratio 0.87, 95% CI 0.32-1.66). Dietary isoflavone intake among young premenopausal women was not related to sex hormone concentrations or anovulation, but was associated with minimally increased SHBG concentrations. These results suggest potential endocrine effects with no subsequent effects on ovulation, easing concerns regarding their impacts on fertility.
评估总异黄酮摄入量与排卵功能的关系，包括健康绝经前妇女的偶发性排卵障碍。
前瞻性队列研究。
大学。
参与者包括 259 名年龄在 18-44 岁之间的健康、有规律月经的女性。
无。
健康绝经前妇女的血清 E2、游离 E2、P、LH、FSH 和 SHBG 浓度及偶发性排卵障碍。
异黄酮摄入量与 E2、游离 E2、P、LH 和 FSH 浓度无关。与第一四分位数（Q1：0.0-0.3mg/d）相比，摄入量最高四分位数（Q4：1.6-78.8mg/d）的 SHBG 浓度显著较高（β=0.09；95%置信区间 0.02-0.16）。
异黄酮摄入量与偶发性排卵障碍无关（Q4 与 Q1：比值比 0.87，95%置信区间 0.32-1.66）。年轻绝经前妇女的饮食异黄酮摄入量与性激素浓度或排卵障碍无关，但与 SHBG 浓度略有升高有关。这些结果表明，其具有潜在的内分泌作用，而对排卵没有后续影响，减轻了对其对生育能力影响的担忧。
