Department of Molecular and Cellular Neuroscience, The Dorris Neuroscience Center, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
Curr Opin Neurobiol. 2013 Dec;23(6):997-1004. doi: 10.1016/j.conb.2013.08.005. Epub 2013 Aug 30.
Exosomes are small extracellular vesicles that mediate intercellular signaling in the brain without requiring direct contact between cells. Although exosomes have been shown to play a role in neurological diseases and in response to nerve trauma, a role for exosome-mediated signaling in brain development and function has not yet been demonstrated. Here we review data building a case for exosome function in the brain.
外泌体是一种小的细胞外囊泡，可在细胞间传递信号而无需细胞间直接接触。虽然已经证明外泌体在神经疾病和神经创伤反应中起作用，但外泌体介导的信号在大脑发育和功能中的作用尚未得到证实。本文综述了支持外泌体在大脑中具有功能的相关数据。
