补体在致死性细菌脂多糖诱导的低血压和凝血变化中的作用。
Role of complement in lethal bacterial lipopolysaccharide-induced hypotensive and coagulative changes.
作者信息
Ulevitch R J, Cochrane C G
出版信息
Infect Immun. 1978 Jan;19(1):204-11. doi: 10.1128/iai.19.1.204-211.1978.
Abstract
The effect of C3 depletion on the multiple pathophysiological changes produced by a lethal dose of Serratia marcescens lipopolysaccharide (LPS) was evaluated. The injection of this LPS into rabbits resulted in biphasic hypotensive changes and thrombocytopenia. These changes were characterized by an acute, transient decrease occurring within minutes after injection followed by a second more gradual decrease beginning 30 to 60 min post-LPS. Prior depletion of C3, with the anticomplementary protein from cobra venom (CoF), did not alter the extent of either the gradual hypotensive and platelet changes or the coagulative and metabolic changes when normal and C3-depleted rabbits were compared. Importantly, the lethal effects of S. marcescens LPS were not reduced by prior depletion of C3. Only the immediate, reversible thrombocytopenia and hypotension were abrogated by C3 depletion.
摘要
评估了C3耗竭对致死剂量粘质沙雷氏菌脂多糖（LPS）所产生的多种病理生理变化的影响。将这种LPS注射到兔子体内会导致双相性低血压变化和血小板减少。这些变化的特征是，注射后数分钟内出现急性、短暂的下降，随后在LPS注射后30至60分钟开始出现第二次更缓慢的下降。当比较正常和C3耗竭的兔子时，预先用眼镜蛇毒抗补体蛋白（CoF）耗竭C3，并未改变逐渐性低血压和血小板变化的程度，也未改变凝血和代谢变化的程度。重要的是，预先耗竭C3并未降低粘质沙雷氏菌LPS的致死作用。只有即刻、可逆的血小板减少和低血压通过C3耗竭得以消除。
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