Ulevitch R J, Cochrane C G
Inflammation. 1977 Sep;2(3):199-216. doi: 10.1007/BF00917596.
The intravenous injection of the anticomplementary protein from cobra venom, cobra factor (CoF),2 induces decreases in mean arterial blood pressure and circulating platelets in rabbits. The changes are rapidly reversed. Both changes require the presence of C3 and occur in rabbits genetically deficient in the sixth component of complement. The hypotensive effects of CoF were blocked by the histamine H2-receptor antagonist burimamide. An acute C3-dependent change in blood pressure and circulating platelets also was demonstrated following the intravenous injection of S. marcescens endotoxin. However, abrogation of these acute changes by C3 depletion did not alter the extent of a second, prolonged fall in blood pressure and platelets induced by S. marcescens endotoxin occurring after 60--90 min. C3 depletion also did not alter the lethal effects of the S. marcescens endotoxin.
静脉注射眼镜蛇毒中的抗补体蛋白——眼镜蛇因子（CoF），可使家兔平均动脉血压降低，循环血小板数量减少。这些变化能迅速逆转。这两种变化都需要C3的存在，且发生在遗传性缺乏补体第六成分的家兔身上。CoF的降压作用被组胺H2受体拮抗剂布立马胺阻断。静脉注射粘质沙雷氏菌内毒素后，也证实了血压和循环血小板出现急性C3依赖性变化。然而，通过消耗C3消除这些急性变化，并未改变粘质沙雷氏菌内毒素在60 - 90分钟后引起的第二次、持续时间较长的血压和血小板下降程度。消耗C3也未改变粘质沙雷氏菌内毒素的致死作用。
