Biomarkers Research Program, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Molecules. 2013 Sep 2;18(9):10671-80. doi: 10.3390/molecules180910671.
While moderate to severe vitamin D deficiency is prevalent in Saudi Arabia, skeletal effects associated with this deficiency are not common in this population. In this interventional study we measured the effects of improving vitamin D status on bone biochemical markers in overweight and obese adult Saudis. A total of 47 volunteers (21 males, 26 females) out of the initial 95 subjects were given verbal advice to expose themselves to sunlight for 5-30 min twice weekly and were encouraged to increase their intake of vitamin D-rich foods. Serum 25(OH)D, osteocalcin, and type 1 collagen cross-linked C-telopeptide (CTx), were measured at baseline and after one year. A significant decrease in the prevalence of vitamin D deficiency was observed (44% to 27%) after one year follow-up (p = 0.025). Also, a parallel significant increase in osteocalcin and a decrease in CTX and osteoprotegerin were observed. The results suggest that a modest increase in vitamin D levels among overweight and obese subjects through the promotion of lifestyle changes for one year have marginal effects in bone turnover markers as well as obesity itself.
尽管沙特阿拉伯普遍存在中重度维生素 D 缺乏症，但该人群中与这种缺乏症相关的骨骼影响并不常见。在这项干预研究中，我们测量了改善超重和肥胖沙特成年人维生素 D 状态对骨骼生化标志物的影响。在最初的 95 名受试者中，共有 47 名志愿者（21 名男性，26 名女性）接受了每周两次暴露在阳光下 5-30 分钟的口头建议，并被鼓励增加富含维生素 D 的食物的摄入量。在基线和一年后测量了血清 25(OH)D、骨钙素和 1 型胶原交联 C 端肽（CTX）。一年随访后，维生素 D 缺乏症的患病率显著下降（从 44%降至 27%）（p = 0.025）。此外，还观察到骨钙素的平行显著增加，CTX 和骨保护素的减少。结果表明，通过促进生活方式改变，使超重和肥胖人群的维生素 D 水平适度增加一年，对骨转换标志物以及肥胖本身的影响微乎其微。
