Im K S, Kim N H, Lim H Y, Kim H W, Shin J I, Sur J H
Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 143-701, Korea. Email:
Vet Pathol. 2014 May;51(3):549-59. doi: 10.1177/0300985813498780. Epub 2013 Sep 3.
Canine mammary tumors (CMTs) are morphologically and biologically heterogeneous, prompting several attempts to classify such tumors on the basis of their histopathological characteristics. Recently, molecular-based analysis methods borrowed from human breast cancer research have also been applied to the classification of CMTs. In this study, canine mammary neoplasms (n = 648) occurring in Korea from 2008 to 2011 were analyzed according to the histological classification and grading system proposed by Goldschmidt et al. Furthermore, randomly selected mammary carcinomas (n = 159) were classified according to the molecular subtype using immunohistochemical characteristics. Canine mammary neoplasia accounted for 52.6% (648/1250) of the tumors in female dogs, and 51.7% (340/648) of these were malignant. All of the carcinoma-anaplastic subtypes were grade III tumors (5/5, 100%), while most of the carcinoma-tubular subtypes (15/18, 83.3%) and carcinoma arising in a complex adenoma/mixed-tumor subtype (115/135, 85.2%) were grade I tumors. Tumor cell invasion into lymphatic vessels was most common in the comedocarcinoma, carcinoma-anaplastic, and inflammatory carcinoma subtypes. The most frequently occurring molecular subtype (70/159, 44%) was luminal A. However, the basal-like subtype was the most malignant and was frequently associated with grade III tumors and lymphatic invasion. The carcinoma-solid subtypes were also often of the basal-like subtype. Reclassification of CMTs using the newly proposed histopathological classification system and molecular subtyping could aid in determining the prognosis and the most suitable anticancer treatment for each case.
犬乳腺肿瘤（CMTs）在形态学和生物学上具有异质性，这促使人们多次尝试根据其组织病理学特征对这类肿瘤进行分类。最近，从人类乳腺癌研究中借鉴的基于分子的分析方法也被应用于CMTs的分类。在本研究中，根据Goldschmidt等人提出的组织学分类和分级系统，对2008年至2011年在韩国发生的犬乳腺肿瘤（n = 648）进行了分析。此外，使用免疫组织化学特征，根据分子亚型对随机选择的乳腺癌（n = 159）进行了分类。犬乳腺肿瘤占雌性犬肿瘤的52.6%（648/1250），其中51.7%（340/648）为恶性。所有的癌-间变亚型均为III级肿瘤（5/5，100%），而大多数癌-管状亚型（15/18，83.3%）和起源于复杂腺瘤/混合瘤亚型的癌（115/135，85.2%）为I级肿瘤。肿瘤细胞侵入淋巴管在粉刺癌、癌-间变和炎性癌亚型中最为常见。最常见的分子亚型是管腔A型（70/159，44%）。然而，基底样亚型是最具恶性的，且经常与III级肿瘤和淋巴管侵犯相关。癌-实性亚型也常为基底样亚型。使用新提出的组织病理学分类系统和分子亚型对CMTs进行重新分类有助于确定每个病例的预后和最合适的抗癌治疗方法。
