双侧乳腺癌的分子和临床病理特征。

Department of Medical Oncology, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515031, PR China.

Sci Rep. 2013;3:2590. doi: 10.1038/srep02590.

In this study, we compared the clinicopathologic characteristics between the bilateral breast cancer (BiBC) and unilateral breast cancer (UBC) and investigated the role of CXC chemokine receptor type 4 (CXCR4) in BiBC. 48 BiBC and 1650 UBC were studied. We found BiBC patients were associated with family history of cancer, invasive lobular histology in the first tumor and an advanced nodal status as compared with UBC patients with. Survival analysis indicated that BiBC was not associated with impaired survival. The time interval between the development of first breast cancer and the contralateral cancer did not correlate with the prognosis. Patients with BiBC were more likely to have bone metastasis (P = 0.011) and visceral metastasis (P < 0.001) than those with UBC. However, CXCR4 was not found in any association with poor clinical outcome and increasing visceral metastasis in BiBC patients.

在这项研究中，我们比较了双侧乳腺癌（BiBC）和单侧乳腺癌（UBC）的临床病理特征，并探讨了 CXC 趋化因子受体 4（CXCR4）在 BiBC 中的作用。研究了 48 例 BiBC 和 1650 例 UBC。我们发现 BiBC 患者与癌症家族史、第一肿瘤的浸润性小叶组织学和淋巴结状态较严重有关，而 UBC 患者则没有。生存分析表明，BiBC 与生存率下降无关。第一例乳腺癌和对侧癌症之间的时间间隔与预后无关。与 UBC 患者相比，BiBC 患者更易发生骨转移（P = 0.011）和内脏转移（P < 0.001）。然而，在 BiBC 患者中，CXCR4 与不良临床结局和内脏转移增加无关。