Cincinnati Sports Medicine and Orthopaedic Center, 7423 Mason Montgomery Road, Cincinnati, OH 45249, USA.
J Bone Joint Surg Am. 2013 Sep 4;95(17):1620-8. doi: 10.2106/JBJS.L.01004.
Tendon injuries often result from excessive or insufficient mechanical loading, impairing the ability of the local tendon cell population to maintain normal tendon function. The resident cell population composing tendon tissue is mechanosensitive, given that the cells are able to alter the extracellular matrix in response to modifications of the local loading environment. Natural tendon healing is insufficient, characterized by improper collagen fibril diameter formation, collagen fibril distribution, and overall fibril misalignment. Current tendon repair rehabilitation protocols focus on implementing early, well-controlled eccentric loading exercises to improve repair outcome. Tissue engineers look toward incorporating mechanical loading regimens to precondition cell populations for the creation of improved biological augmentations for tendon repair.
肌腱损伤通常是由于机械负荷过大或不足引起的，这会损害局部肌腱细胞群体维持正常肌腱功能的能力。组成肌腱组织的常驻细胞群体具有机械敏感性，因为细胞能够响应局部加载环境的变化来改变细胞外基质。自然的肌腱愈合是不足的，其特征是胶原纤维直径形成不当、胶原纤维分布和整体纤维排列紊乱。目前的肌腱修复康复方案侧重于实施早期、良好控制的离心加载运动，以改善修复效果。组织工程师希望通过施加机械负荷方案来对细胞群体进行预处理，从而为肌腱修复创造更好的生物增强物。
