Author's Affiliation: Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Cancer Epidemiol Biomarkers Prev. 2013 Nov;22(11):1927-30. doi: 10.1158/1055-9965.EPI-13-0612. Epub 2013 Sep 5.
An uncommon immunoglobulin GM (γ marker) genotype has been reported to be strongly associated with susceptibility to neuroblastoma, but the mechanism(s) underlying this association is not known. Increasing evidence implicates human cytomegalovirus (HCMV) in the pathogenesis of neuroblastoma. HCMV has evolved a large repertoire of sophisticated strategies to evade host immunosurveillance. Particular GM alleles modulate an immunoevasion strategy of HCMV and contribute to humoral immunity to HCMV epitopes, attributes that provide possible mechanistic explanations for their involvement in the etiopathogenesis of neuroblastoma and explain, at least partially, why a common virus causes/spurs an uncommon cancer.
一种罕见的免疫球蛋白 GM（γ 标志物）基因型已被报道与神经母细胞瘤的易感性密切相关，但这种关联的机制尚不清楚。越来越多的证据表明人类巨细胞病毒（HCMV）参与了神经母细胞瘤的发病机制。HCMV 已经进化出了大量复杂的策略来逃避宿主的免疫监视。特定的 GM 等位基因调节 HCMV 的免疫逃避策略，并有助于针对 HCMV 表位的体液免疫，这些特性为它们参与神经母细胞瘤的病因发病机制提供了可能的机制解释，并至少部分解释了为什么一种常见病毒会引发/促进一种罕见癌症。
