Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD.
Epilepsy Curr. 2013 Jul;13(4):172-6. doi: 10.5698/1535-7597-13.4.172.
Errors in the generation of the inhibitory GABAergic interneurons of the cerebral cortex and hippocampus have variable consequences. Studies of the molecular pathways of interneuron development reveal genes that are associated with human epilepsies. Animal models of gene variants exhibit seizures and abnormal electroencephalographic activity, providing unique models for discovering better treatments for individual forms of epilepsy.
大脑皮层和海马区抑制性 GABA 能中间神经元生成错误具有多种后果。中间神经元发育的分子途径研究揭示了与人类癫痫相关的基因。基因变异的动物模型表现出癫痫发作和异常脑电图活动，为发现针对特定类型癫痫的更好治疗方法提供了独特的模型。
