神经元发育与癫痫：早期遗传缺陷导致癫痫发作和易感性的长期后果。
Interneuron development and epilepsy: early genetic defects cause long-term consequences in seizures and susceptibility.
机构信息
Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD.
出版信息
Epilepsy Curr. 2013 Jul;13(4):172-6. doi: 10.5698/1535-7597-13.4.172.
Abstract
Errors in the generation of the inhibitory GABAergic interneurons of the cerebral cortex and hippocampus have variable consequences. Studies of the molecular pathways of interneuron development reveal genes that are associated with human epilepsies. Animal models of gene variants exhibit seizures and abnormal electroencephalographic activity, providing unique models for discovering better treatments for individual forms of epilepsy.
摘要
大脑皮层和海马区抑制性 GABA 能中间神经元生成错误具有多种后果。中间神经元发育的分子途径研究揭示了与人类癫痫相关的基因。基因变异的动物模型表现出癫痫发作和异常脑电图活动，为发现针对特定类型癫痫的更好治疗方法提供了独特的模型。
相似文献
1
Interneuron development and epilepsy: early genetic defects cause long-term consequences in seizures and susceptibility.神经元发育与癫痫：早期遗传缺陷导致癫痫发作和易感性的长期后果。
Epilepsy Curr. 2013 Jul;13(4):172-6. doi: 10.5698/1535-7597-13.4.172.
2
The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death.γ-原钙黏蛋白在发育性细胞死亡期间调节 GABA 能中间神经元的存活。
J Neurosci. 2020 Nov 4;40(45):8652-8668. doi: 10.1523/JNEUROSCI.1636-20.2020. Epub 2020 Oct 15.
3
Synapsin II Regulation of GABAergic Synaptic Transmission Is Dependent on Interneuron Subtype.突触结合蛋白II对GABA能突触传递的调节取决于中间神经元亚型。
J Neurosci. 2017 Feb 15;37(7):1757-1771. doi: 10.1523/JNEUROSCI.0844-16.2016. Epub 2017 Jan 13.
4
Disruption of interneuron development.中间神经元发育的破坏。
Epilepsia. 2005;46 Suppl 7:22-8. doi: 10.1111/j.1528-1167.2005.00305.x.
5
A Transient Developmental Window of Fast-Spiking Interneuron Dysfunction in a Mouse Model of Dravet Syndrome.Dravet 综合征小鼠模型中快速棘突神经元功能障碍的短暂发育窗口。
J Neurosci. 2018 Sep 5;38(36):7912-7927. doi: 10.1523/JNEUROSCI.0193-18.2018. Epub 2018 Aug 13.
6
[Advances in the physiopathology of epileptogenesis: molecular aspects].[癫痫发生的病理生理学进展：分子层面]
Rev Neurol. 2002;34(5):409-29.
7
Interneuron transplantation: a prospective surgical therapy for medically refractory epilepsy.神经前体细胞移植：一种针对药物难治性癫痫的有前景的手术治疗方法。
Neurosurg Focus. 2020 Apr 1;48(4):E18. doi: 10.3171/2020.2.FOCUS19955.
8
Interneuron dysfunction in epilepsy: An experimental approach using immature brain insults to induce neuronal migration disorders.癫痫中的中间神经元功能障碍：使用不成熟的脑损伤诱导神经元迁移障碍的实验方法。
Epilepsy Res. 2019 Oct;156:106185. doi: 10.1016/j.eplepsyres.2019.106185. Epub 2019 Aug 5.
9
Preferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility.小白蛋白中间神经元中Scn1a的优先失活会增加癫痫易感性。
Neurobiol Dis. 2013 Jan;49:211-20. doi: 10.1016/j.nbd.2012.08.012. Epub 2012 Aug 25.
10
Impairment of Sharp-Wave Ripples in a Murine Model of Dravet Syndrome.Dravet 综合征小鼠模型中海马尖波涟漪的损伤。
J Neurosci. 2019 Nov 13;39(46):9251-9260. doi: 10.1523/JNEUROSCI.0890-19.2019. Epub 2019 Sep 19.
引用本文的文献
1
Overexpression of BDNF Suppresses the Epileptiform Activity in Cortical Neurons of Heterozygous Mice with a Transcription Factor Sip1 Deletion.BDNF 过表达抑制转录因子 Sip1 缺失杂合子小鼠皮质神经元的癫痫样活动。
Int J Mol Sci. 2024 Sep 30;25(19):10537. doi: 10.3390/ijms251910537.
2
Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex.结节性硬化症中内侧神经节隆起衍生的中间神经元中 GABA 能调节受损和发育不成熟。
Acta Neuropathol. 2024 May 7;147(1):80. doi: 10.1007/s00401-024-02737-7.
3
mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment.mTOR 与癫痫中的神经炎症：对疾病进展和治疗的影响。
Nat Rev Neurosci. 2024 May;25(5):334-350. doi: 10.1038/s41583-024-00805-1. Epub 2024 Mar 26.
4
Factors and Mechanisms of Thyroid Hormone Activity in the Brain: Possible Role in Recovery and Protection.脑内甲状腺激素活性的影响因素和机制：在恢复和保护中的可能作用。
Biomolecules. 2024 Feb 7;14(2):198. doi: 10.3390/biom14020198.
5
Neuroimaging features of WOREE syndrome: a mini-review of the literature.沃里综合征的神经影像学特征：文献综述
Front Pediatr. 2023 Dec 15;11:1301166. doi: 10.3389/fped.2023.1301166. eCollection 2023.
6
Is tuberous sclerosis complex-associated autism a preventable and treatable disorder?结节性硬化症相关自闭症是否可预防和治疗？
World J Pediatr. 2024 Jan;20(1):40-53. doi: 10.1007/s12519-023-00762-2. Epub 2023 Oct 25.
7
Local Thyroid Hormone Action in Brain Development.脑发育中的局部甲状腺激素作用。
Int J Mol Sci. 2023 Aug 2;24(15):12352. doi: 10.3390/ijms241512352.
8
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia.齿状回中的兴奋性生长抑素中间神经元驱动皮质发育不良中的广泛癫痫网络。
Signal Transduct Target Ther. 2023 May 17;8(1):186. doi: 10.1038/s41392-023-01404-9.
9
Epileptogenesis in tuberous sclerosis complex-related developmental and epileptic encephalopathy.结节性硬化症相关发育性和癫痫性脑病中的癫痫发生机制。
Brain. 2023 Jul 3;146(7):2694-2710. doi: 10.1093/brain/awad048.
10
Parvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention.小清蛋白在癫痫和精神疾病共病中的作用：从机制到干预
Front Integr Neurosci. 2022 Feb 17;16:765324. doi: 10.3389/fnint.2022.765324. eCollection 2022.
本文引用的文献
1
MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways.MEF2C 杂合不足的特征为持续多动、癫痫发作多变，并且在背侧和腹侧神经元发育途径中发挥作用。
Neurogenetics. 2013 May;14(2):99-111. doi: 10.1007/s10048-013-0356-y. Epub 2013 Feb 7.
2
New insights into the classification and nomenclature of cortical GABAergic interneurons.皮层 GABA 能中间神经元分类和命名的新见解。
Nat Rev Neurosci. 2013 Mar;14(3):202-16. doi: 10.1038/nrn3444. Epub 2013 Feb 6.
3
Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.Dlg1&2 依赖性表达的 Zfhx1b（Sip1，Zeb2）调节皮质和纹状体中间神经元之间命运的转换。
Neuron. 2013 Jan 9;77(1):83-98. doi: 10.1016/j.neuron.2012.11.035.
4
Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1.皮质中间神经元的定向迁移依赖于 Sip1 的细胞自主作用。
Neuron. 2013 Jan 9;77(1):70-82. doi: 10.1016/j.neuron.2012.11.009.
5
Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms.中间神经元，中断：ARX 突变和 X 连锁婴儿痉挛的分子发病机制。
Curr Opin Neurobiol. 2012 Oct;22(5):859-65. doi: 10.1016/j.conb.2012.04.006. Epub 2012 May 5.
6
Loss of COUP-TFI alters the balance between caudal ganglionic eminence- and medial ganglionic eminence-derived cortical interneurons and results in resistance to epilepsy.COUP-TFI 缺失改变了尾状核隆起和内侧神经节隆起来源的皮质中间神经元之间的平衡，导致癫痫耐药。
J Neurosci. 2011 Mar 23;31(12):4650-62. doi: 10.1523/JNEUROSCI.6580-10.2011.
7
Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo.Wnt5a 是 Dlx 同源基因的转录靶标，可促进体外和体内中间神经元祖细胞的分化。
J Neurosci. 2011 Feb 16;31(7):2675-87. doi: 10.1523/JNEUROSCI.3110-10.2011.
8
Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons.Dlx5 和 Dlx6 调节表达 parvalbumin 的皮质中间神经元的发育。
J Neurosci. 2010 Apr 14;30(15):5334-45. doi: 10.1523/JNEUROSCI.5963-09.2010.
9
Hepatocyte growth factor (HGF) modulates GABAergic inhibition and seizure susceptibility.肝细胞生长因子（HGF）调节 GABA 能抑制和癫痫易感性。
Exp Neurol. 2010 Jan;221(1):129-35. doi: 10.1016/j.expneurol.2009.10.011. Epub 2009 Oct 22.
10
Regionalized loss of parvalbumin interneurons in the cerebral cortex of mice with deficits in GFRalpha1 signaling.GFRalpha1信号通路缺陷的小鼠大脑皮质中小清蛋白中间神经元的区域性缺失
J Neurosci. 2009 Aug 26;29(34):10695-705. doi: 10.1523/JNEUROSCI.2658-09.2009.
Zotero 插件