1例人类免疫缺陷病毒相关的间变性淋巴瘤激酶蛋白阴性间变性大细胞淋巴瘤病例报告
A case report of human immunodeficiency virus-associated anaplastic lymphoma kinase protein-negative anaplastic large cell lymphoma.
作者信息
Taniai Hiroaki, Furusyo Norihiro, Murata Masayuki, Mitsumoto Fujiko, Shimizu Motohiro, Toyoda Kazuhiro, Ogawa Eiichi, Kainuma Mosaburo, Okada Kyoko, Hayashi Jun
机构信息
Department of General Internal Medicine, Kyushu University Hospital, 3-1-1, Maidashi, Higashi-Ku, Fukuoka, 812-8582 Japan.
出版信息
Springerplus. 2013 Aug 23;2:400. doi: 10.1186/2193-1801-2-400. eCollection 2013.
Human immunodeficiency virus (HIV)-associated anaplastic large cell lymphoma (ALCL) is not so common, and anaplastic lymphoma kinase protein (ALK)-negative ALCL is rare and has a low survival rate. We report a case of a 31-year-old Japanese man diagnosed with HIV-associated ALK-negative ALCL who presented with long-lasting fever of unknown origin. The diagnosis was based on a full work-up that included inguinal lymph-node biopsy. Eight-cycle chemotherapy that included cyclophosphamide, doxorubicin, vincristine, and prednisone in addition to antiretroviral therapy for HIV infection provided a complete remission of his ALCL and over 5-year survival for him.
人类免疫缺陷病毒（HIV）相关的间变性大细胞淋巴瘤（ALCL）并不常见，而间变性淋巴瘤激酶蛋白（ALK）阴性的ALCL则更为罕见，生存率较低。我们报告了一例31岁的日本男性病例，该患者被诊断为HIV相关的ALK阴性ALCL，表现为长期不明原因发热。诊断基于包括腹股沟淋巴结活检在内的全面检查。除针对HIV感染的抗逆转录病毒治疗外，包含环磷酰胺、阿霉素、长春新碱和泼尼松的八周期化疗使他的ALCL完全缓解，并存活了5年以上。
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