Taniai Hiroaki, Furusyo Norihiro, Murata Masayuki, Mitsumoto Fujiko, Shimizu Motohiro, Toyoda Kazuhiro, Ogawa Eiichi, Kainuma Mosaburo, Okada Kyoko, Hayashi Jun
Department of General Internal Medicine, Kyushu University Hospital, 3-1-1, Maidashi, Higashi-Ku, Fukuoka, 812-8582 Japan.
Springerplus. 2013 Aug 23;2:400. doi: 10.1186/2193-1801-2-400. eCollection 2013.
Human immunodeficiency virus (HIV)-associated anaplastic large cell lymphoma (ALCL) is not so common, and anaplastic lymphoma kinase protein (ALK)-negative ALCL is rare and has a low survival rate. We report a case of a 31-year-old Japanese man diagnosed with HIV-associated ALK-negative ALCL who presented with long-lasting fever of unknown origin. The diagnosis was based on a full work-up that included inguinal lymph-node biopsy. Eight-cycle chemotherapy that included cyclophosphamide, doxorubicin, vincristine, and prednisone in addition to antiretroviral therapy for HIV infection provided a complete remission of his ALCL and over 5-year survival for him.
人类免疫缺陷病毒（HIV）相关的间变性大细胞淋巴瘤（ALCL）并不常见，而间变性淋巴瘤激酶蛋白（ALK）阴性的ALCL则更为罕见，生存率较低。我们报告了一例31岁的日本男性病例，该患者被诊断为HIV相关的ALK阴性ALCL，表现为长期不明原因发热。诊断基于包括腹股沟淋巴结活检在内的全面检查。除针对HIV感染的抗逆转录病毒治疗外，包含环磷酰胺、阿霉素、长春新碱和泼尼松的八周期化疗使他的ALCL完全缓解，并存活了5年以上。
