Li Jin-Ping, Wang Xiao-Jing, Zeng Ying, Lin Qing, Mo Xin-Min, Liu Shi-Jie, Yang Jun
School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(11):1816-9.
To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.
Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT.
Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05).
Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.
观察补骨脂定对去卵巢大鼠的影响，并初步探讨其作用机制。
将60只雌性Sprague-Dawley大鼠分为5组：假手术组、模型组、补骨脂定低剂量组（4mg·kg⁻¹）、补骨脂定高剂量组（16mg·kg⁻¹）和壮骨止痛胶囊组，每组12只。13周后，采集大鼠血液和骨骼样本，检测骨密度、骨生物化学指标、病理形态学、血清E2和CT。
补骨脂定可上调去卵巢大鼠腰椎和股骨的骨密度（P<0.05）、股骨最大弯曲强度（P<0.05）以及血清E2和CT（P<0.05）。
补骨脂定对绝经后抗骨质疏松具有良好的活性作用。其机制可能与E2和CT等途径有关。
